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Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer
Even though immune checkpoint inhibitors (ICIs) are effective on multiple cancer types, there are still many non-responding patients. A possible factor put forward that may influence the efficacy of ICIs is the gut microbiota. Additionally, faecal microbiota transplantation may enhance efficacy of I...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409158/ https://www.ncbi.nlm.nih.gov/pubmed/34539138 http://dx.doi.org/10.3748/wjg.v27.i32.5362 |
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author | Kang, Yong-Bo Cai, Yue |
author_facet | Kang, Yong-Bo Cai, Yue |
author_sort | Kang, Yong-Bo |
collection | PubMed |
description | Even though immune checkpoint inhibitors (ICIs) are effective on multiple cancer types, there are still many non-responding patients. A possible factor put forward that may influence the efficacy of ICIs is the gut microbiota. Additionally, faecal microbiota transplantation may enhance efficacy of ICIs. Nevertheless, the data available in this field are insufficient, and relevant scientific work has just commenced. As a result, the current work reviewed the latest research on the association of gut microbiota with ICI treatments based on anti-programmed cell death protein 1 antibody and anti- cytotoxic T-lymphocyte-associated protein 4 antibody and explored the therapeutic potential of faecal microbiota transplantation in combination with ICI therapy in the future. |
format | Online Article Text |
id | pubmed-8409158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-84091582021-09-16 Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer Kang, Yong-Bo Cai, Yue World J Gastroenterol Minireviews Even though immune checkpoint inhibitors (ICIs) are effective on multiple cancer types, there are still many non-responding patients. A possible factor put forward that may influence the efficacy of ICIs is the gut microbiota. Additionally, faecal microbiota transplantation may enhance efficacy of ICIs. Nevertheless, the data available in this field are insufficient, and relevant scientific work has just commenced. As a result, the current work reviewed the latest research on the association of gut microbiota with ICI treatments based on anti-programmed cell death protein 1 antibody and anti- cytotoxic T-lymphocyte-associated protein 4 antibody and explored the therapeutic potential of faecal microbiota transplantation in combination with ICI therapy in the future. Baishideng Publishing Group Inc 2021-08-28 2021-08-28 /pmc/articles/PMC8409158/ /pubmed/34539138 http://dx.doi.org/10.3748/wjg.v27.i32.5362 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Kang, Yong-Bo Cai, Yue Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
title | Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
title_full | Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
title_fullStr | Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
title_full_unstemmed | Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
title_short | Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
title_sort | faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409158/ https://www.ncbi.nlm.nih.gov/pubmed/34539138 http://dx.doi.org/10.3748/wjg.v27.i32.5362 |
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