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New mechanism of partial duplication and deletion of chromosome 8: A case report

BACKGROUND: During meiosis, the recombination of homologous chromosomes produces some new heritable mutations, which are the basis of biological evolution and diversity. However, when there is pericentric inversion of chromosomes, unbalanced gametes will be formed in the process of germ cell meiosis...

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Autores principales: Jiang, Yan, Tang, Shuang, He, Fang, Yuan, Jue-Xin, Zhang, Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409188/
https://www.ncbi.nlm.nih.gov/pubmed/34540970
http://dx.doi.org/10.12998/wjcc.v9.i24.7139
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author Jiang, Yan
Tang, Shuang
He, Fang
Yuan, Jue-Xin
Zhang, Zhu
author_facet Jiang, Yan
Tang, Shuang
He, Fang
Yuan, Jue-Xin
Zhang, Zhu
author_sort Jiang, Yan
collection PubMed
description BACKGROUND: During meiosis, the recombination of homologous chromosomes produces some new heritable mutations, which are the basis of biological evolution and diversity. However, when there is pericentric inversion of chromosomes, unbalanced gametes will be formed in the process of germ cell meiosis. CASE SUMMARY: A 23-year-old pregnant woman at 25 wk of gestation wanted to terminate her pregnancy due to fetal chromosomal abnormalities. She had no exposure to toxic or hazardous substances before and during pregnancy, no history of medication usage during pregnancy, and she underwent cystectomy of ovarian cysts in 2017. On the second day of the 16(th) week of gestation, non-invasive prenatal testing showed chromosome 8 copy number variation. Following genetic counseling, her pregnancy was terminated. CONCLUSION: Recombinant offspring chromosome is rarely seen when the inversion segment is shorter than one-third of the chromosome length. In terms of the mechanism of chromosome 8 duplication/deletion occurrence, attention should be paid to the production of unbalanced gametes by the pairing of homologous chromosome during meiosis, and the possibility of mitotic recombination exchange as well.
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spelling pubmed-84091882021-09-16 New mechanism of partial duplication and deletion of chromosome 8: A case report Jiang, Yan Tang, Shuang He, Fang Yuan, Jue-Xin Zhang, Zhu World J Clin Cases Case Report BACKGROUND: During meiosis, the recombination of homologous chromosomes produces some new heritable mutations, which are the basis of biological evolution and diversity. However, when there is pericentric inversion of chromosomes, unbalanced gametes will be formed in the process of germ cell meiosis. CASE SUMMARY: A 23-year-old pregnant woman at 25 wk of gestation wanted to terminate her pregnancy due to fetal chromosomal abnormalities. She had no exposure to toxic or hazardous substances before and during pregnancy, no history of medication usage during pregnancy, and she underwent cystectomy of ovarian cysts in 2017. On the second day of the 16(th) week of gestation, non-invasive prenatal testing showed chromosome 8 copy number variation. Following genetic counseling, her pregnancy was terminated. CONCLUSION: Recombinant offspring chromosome is rarely seen when the inversion segment is shorter than one-third of the chromosome length. In terms of the mechanism of chromosome 8 duplication/deletion occurrence, attention should be paid to the production of unbalanced gametes by the pairing of homologous chromosome during meiosis, and the possibility of mitotic recombination exchange as well. Baishideng Publishing Group Inc 2021-08-26 2021-08-26 /pmc/articles/PMC8409188/ /pubmed/34540970 http://dx.doi.org/10.12998/wjcc.v9.i24.7139 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Jiang, Yan
Tang, Shuang
He, Fang
Yuan, Jue-Xin
Zhang, Zhu
New mechanism of partial duplication and deletion of chromosome 8: A case report
title New mechanism of partial duplication and deletion of chromosome 8: A case report
title_full New mechanism of partial duplication and deletion of chromosome 8: A case report
title_fullStr New mechanism of partial duplication and deletion of chromosome 8: A case report
title_full_unstemmed New mechanism of partial duplication and deletion of chromosome 8: A case report
title_short New mechanism of partial duplication and deletion of chromosome 8: A case report
title_sort new mechanism of partial duplication and deletion of chromosome 8: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409188/
https://www.ncbi.nlm.nih.gov/pubmed/34540970
http://dx.doi.org/10.12998/wjcc.v9.i24.7139
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