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Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report

BACKGROUND: We present a rare case of status epilepticus in a 56-year-old man which arose as a complication after vaccination with the coronavirus disease 2019 (COVID-19) mRNA-1273 vaccine. The patient's history included well-compensated secondary epilepsy. The root cause of the situation was a...

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Autores principales: Šín, Robin, Štruncová, Denisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409199/
https://www.ncbi.nlm.nih.gov/pubmed/34540981
http://dx.doi.org/10.12998/wjcc.v9.i24.7218
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author Šín, Robin
Štruncová, Denisa
author_facet Šín, Robin
Štruncová, Denisa
author_sort Šín, Robin
collection PubMed
description BACKGROUND: We present a rare case of status epilepticus in a 56-year-old man which arose as a complication after vaccination with the coronavirus disease 2019 (COVID-19) mRNA-1273 vaccine. The patient's history included well-compensated secondary epilepsy. The root cause of the situation was a fever which had developed as a side effect of the vaccination. CASE SUMMARY: A 56-year-old man received the first dose of mRNA-1273 vaccine against the severe acute respiratory syndrome-coronavirus-2. The vaccine was administered intramuscularly (100 mg, 0.5 mL). The next morning the man was found to be suffering from fever and headaches while at the same time experiencing general weakness. He lost consciousness suddenly and experienced generalized clonic seizures which turned into status epilepticus. When the Emergency Medical Service arrived the patient was unconscious with spontaneous breathing and generalized clonic seizures. It was necessary to administer diazepam repeatedly. It was also necessary to administer high doses of levetiracetam and temporary propofol. The status epilepticus was brought under control approximately 90 min after the patient’s transport to the Emergency Department. A follow-up electroencephalogram no longer revealed abnormal indications of epileptic fit. The patient was temporarily hospitalized in the Intensive Care Unit and after seven days care was discharged without any further apparent effects. CONCLUSION: There is currently no specific treatment against COVID-19. Therefore, the benefits of COVID-19 vaccine protection outweigh the risks.
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spelling pubmed-84091992021-09-16 Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report Šín, Robin Štruncová, Denisa World J Clin Cases Case Report BACKGROUND: We present a rare case of status epilepticus in a 56-year-old man which arose as a complication after vaccination with the coronavirus disease 2019 (COVID-19) mRNA-1273 vaccine. The patient's history included well-compensated secondary epilepsy. The root cause of the situation was a fever which had developed as a side effect of the vaccination. CASE SUMMARY: A 56-year-old man received the first dose of mRNA-1273 vaccine against the severe acute respiratory syndrome-coronavirus-2. The vaccine was administered intramuscularly (100 mg, 0.5 mL). The next morning the man was found to be suffering from fever and headaches while at the same time experiencing general weakness. He lost consciousness suddenly and experienced generalized clonic seizures which turned into status epilepticus. When the Emergency Medical Service arrived the patient was unconscious with spontaneous breathing and generalized clonic seizures. It was necessary to administer diazepam repeatedly. It was also necessary to administer high doses of levetiracetam and temporary propofol. The status epilepticus was brought under control approximately 90 min after the patient’s transport to the Emergency Department. A follow-up electroencephalogram no longer revealed abnormal indications of epileptic fit. The patient was temporarily hospitalized in the Intensive Care Unit and after seven days care was discharged without any further apparent effects. CONCLUSION: There is currently no specific treatment against COVID-19. Therefore, the benefits of COVID-19 vaccine protection outweigh the risks. Baishideng Publishing Group Inc 2021-08-26 2021-08-26 /pmc/articles/PMC8409199/ /pubmed/34540981 http://dx.doi.org/10.12998/wjcc.v9.i24.7218 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Šín, Robin
Štruncová, Denisa
Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report
title Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report
title_full Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report
title_fullStr Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report
title_full_unstemmed Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report
title_short Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: A case report
title_sort status epilepticus as a complication after covid-19 mrna-1273 vaccine: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409199/
https://www.ncbi.nlm.nih.gov/pubmed/34540981
http://dx.doi.org/10.12998/wjcc.v9.i24.7218
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