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Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis
BACKGROUND: Peptic ulcer (PU) is more prevalent in patients with liver cirrhosis. The role of Helicobacter pylori (H. pylori) infection in the pathogenesis of PU in patients with cirrhosis is still not elucidated. AIM: To perform a meta-analysis on the prevalence of H. pylori infection and PU and th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409208/ https://www.ncbi.nlm.nih.gov/pubmed/34540962 http://dx.doi.org/10.12998/wjcc.v9.i24.7073 |
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author | Wei, Lin Ding, Hui-Guo |
author_facet | Wei, Lin Ding, Hui-Guo |
author_sort | Wei, Lin |
collection | PubMed |
description | BACKGROUND: Peptic ulcer (PU) is more prevalent in patients with liver cirrhosis. The role of Helicobacter pylori (H. pylori) infection in the pathogenesis of PU in patients with cirrhosis is still not elucidated. AIM: To perform a meta-analysis on the prevalence of H. pylori infection and PU and their association in liver cirrhosis patients. METHODS: We searched PubMed, EMBASE, Web of Science, Cochrane, CNKI, Wangfang, and CQVIP databases from inception to July 10, 2020. Odds ratio (OR) and 95% confidence interval (CI) were pooled using a random-effects model. The statistical heterogeneity among studies (I(2)-index), subgroup analyses, regression analysis, sensitivity analysis, and the possibility of publication bias were assessed. RESULTS: A total of 14 studies (13 cross-sectional studies; 1 cohort study) involving 2775 individuals (611 cases with PU and 2164 controls) were included in our meta-analysis. The prevalence of PU in patients with cirrhosis was 22%. The prevalence of H. pylori infection was 65.6% in cirrhotic patients with PU, and 52.5% in those without. The pooled overall OR was 1.73 (95%CI: 1.16-2.56, I(2) = 66.2%, P < 0.001, Z = 2.7, P(z) < 0.05). We did not find the cause of heterogeneity in the subgroup analyses and meta-regression analysis except for one study. Funnel plot did not show significant publication bias. The results of Begg’s test and Egger’s test indicated no evidence of substantial publication bias (P(Begg) = 0.732, P(Egger) = 0.557). CONCLUSION: There is a weakly positive association between H. pylori infection and PU in patients with liver cirrhosis. It is suggested that H. pylori infection may play a role in the pathogenesis of PU in liver cirrhotic patients. |
format | Online Article Text |
id | pubmed-8409208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-84092082021-09-16 Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis Wei, Lin Ding, Hui-Guo World J Clin Cases Meta-Analysis BACKGROUND: Peptic ulcer (PU) is more prevalent in patients with liver cirrhosis. The role of Helicobacter pylori (H. pylori) infection in the pathogenesis of PU in patients with cirrhosis is still not elucidated. AIM: To perform a meta-analysis on the prevalence of H. pylori infection and PU and their association in liver cirrhosis patients. METHODS: We searched PubMed, EMBASE, Web of Science, Cochrane, CNKI, Wangfang, and CQVIP databases from inception to July 10, 2020. Odds ratio (OR) and 95% confidence interval (CI) were pooled using a random-effects model. The statistical heterogeneity among studies (I(2)-index), subgroup analyses, regression analysis, sensitivity analysis, and the possibility of publication bias were assessed. RESULTS: A total of 14 studies (13 cross-sectional studies; 1 cohort study) involving 2775 individuals (611 cases with PU and 2164 controls) were included in our meta-analysis. The prevalence of PU in patients with cirrhosis was 22%. The prevalence of H. pylori infection was 65.6% in cirrhotic patients with PU, and 52.5% in those without. The pooled overall OR was 1.73 (95%CI: 1.16-2.56, I(2) = 66.2%, P < 0.001, Z = 2.7, P(z) < 0.05). We did not find the cause of heterogeneity in the subgroup analyses and meta-regression analysis except for one study. Funnel plot did not show significant publication bias. The results of Begg’s test and Egger’s test indicated no evidence of substantial publication bias (P(Begg) = 0.732, P(Egger) = 0.557). CONCLUSION: There is a weakly positive association between H. pylori infection and PU in patients with liver cirrhosis. It is suggested that H. pylori infection may play a role in the pathogenesis of PU in liver cirrhotic patients. Baishideng Publishing Group Inc 2021-08-26 2021-08-26 /pmc/articles/PMC8409208/ /pubmed/34540962 http://dx.doi.org/10.12998/wjcc.v9.i24.7073 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Meta-Analysis Wei, Lin Ding, Hui-Guo Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis |
title | Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis |
title_full | Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis |
title_fullStr | Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis |
title_full_unstemmed | Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis |
title_short | Helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: An updated meta-analysis |
title_sort | helicobacter pylori infection and peptic ulcer disease in cirrhotic patients: an updated meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409208/ https://www.ncbi.nlm.nih.gov/pubmed/34540962 http://dx.doi.org/10.12998/wjcc.v9.i24.7073 |
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