Recent advances on visual cycle protein research and progress on clinical translation

Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research adv...

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Autores principales: Ooi, Xin Yee, Khan, Rujman, Choudhury, Anjalee, Elisarraras, Francisco Xavier, Grigsby, Jeff, Obregon, Brandi, Tsin, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409245/
https://www.ncbi.nlm.nih.gov/pubmed/34476420
http://dx.doi.org/10.46439/ophthalmology.2.017
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author Ooi, Xin Yee
Khan, Rujman
Choudhury, Anjalee
Elisarraras, Francisco Xavier
Grigsby, Jeff
Obregon, Brandi
Tsin, Andrew
author_facet Ooi, Xin Yee
Khan, Rujman
Choudhury, Anjalee
Elisarraras, Francisco Xavier
Grigsby, Jeff
Obregon, Brandi
Tsin, Andrew
author_sort Ooi, Xin Yee
collection PubMed
description Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber’s congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt’s disease.
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spelling pubmed-84092452021-09-01 Recent advances on visual cycle protein research and progress on clinical translation Ooi, Xin Yee Khan, Rujman Choudhury, Anjalee Elisarraras, Francisco Xavier Grigsby, Jeff Obregon, Brandi Tsin, Andrew Arch Clin Exp Ophthalmol Article Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber’s congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt’s disease. 2020-09-08 2020 /pmc/articles/PMC8409245/ /pubmed/34476420 http://dx.doi.org/10.46439/ophthalmology.2.017 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Ooi, Xin Yee
Khan, Rujman
Choudhury, Anjalee
Elisarraras, Francisco Xavier
Grigsby, Jeff
Obregon, Brandi
Tsin, Andrew
Recent advances on visual cycle protein research and progress on clinical translation
title Recent advances on visual cycle protein research and progress on clinical translation
title_full Recent advances on visual cycle protein research and progress on clinical translation
title_fullStr Recent advances on visual cycle protein research and progress on clinical translation
title_full_unstemmed Recent advances on visual cycle protein research and progress on clinical translation
title_short Recent advances on visual cycle protein research and progress on clinical translation
title_sort recent advances on visual cycle protein research and progress on clinical translation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409245/
https://www.ncbi.nlm.nih.gov/pubmed/34476420
http://dx.doi.org/10.46439/ophthalmology.2.017
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