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In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin

Unfractionated heparin (UFH) is an anionic glycosaminoglycan that is widely used to prevent blood clotting. However, in certain cases, unwanted side effects can require it to be neutralized. Protamine sulfate (PS), a basic peptide rich in arginine, is the only approved antagonist for UFH neutralizat...

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Detalles Bibliográficos
Autores principales:	Li, Tong, Meng, Zhiyun, Zhu, Xiaoxia, Gan, Hui, Gu, Ruolan, Wu, Zhuona, Liu, Taoyun, Han, Peng, Gao, Jiarui, Han, Su, Dou, Guifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409304/ https://www.ncbi.nlm.nih.gov/pubmed/34184429 http://dx.doi.org/10.1002/2211-5463.13240

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