Antitumor effect of WEE1 blockade as monotherapy or in combination with cisplatin in urothelial cancer

Overcoming cisplatin (CDDP) resistance is a major issue in urothelial cancer (UC), in which CDDP‐based chemotherapy is the first‐line treatment. WEE1, a G(2)/M checkpoint kinase, confers chemoresistance in response to genotoxic agents. However, the efficacy of WEE1 blockade in UC has not been report...

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Detalles Bibliográficos
Autores principales: Murakami, Kaoru, Kita, Yuki, Sakatani, Toru, Hamada, Akihiro, Mizuno, Kei, Nakamura, Kenji, Takada, Hideaki, Matsumoto, Keiyu, Sano, Takeshi, Goto, Takayuki, Akamatsu, Shusuke, Saito, Ryoichi, Tsuruyama, Tatsuaki, Ogawa, Osamu, Kobayashi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409401/
https://www.ncbi.nlm.nih.gov/pubmed/34212455
http://dx.doi.org/10.1111/cas.15051

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