Cargando…
TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways
Acute myeloid leukemia (AML) is hierarchically organized by self‐renewing leukemic stem cells (LSCs). LSCs originate from hematopoietic stem cells (HSCs) by acquiring multistep leukemogenic events. To specifically eradicate LSCs, while keeping normal HSCs intact, the discrimination of LSCs from HSCs...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409405/ https://www.ncbi.nlm.nih.gov/pubmed/34159709 http://dx.doi.org/10.1111/cas.15042 |
_version_ | 1783746986041671680 |
---|---|
author | Kikushige, Yoshikane |
author_facet | Kikushige, Yoshikane |
author_sort | Kikushige, Yoshikane |
collection | PubMed |
description | Acute myeloid leukemia (AML) is hierarchically organized by self‐renewing leukemic stem cells (LSCs). LSCs originate from hematopoietic stem cells (HSCs) by acquiring multistep leukemogenic events. To specifically eradicate LSCs, while keeping normal HSCs intact, the discrimination of LSCs from HSCs is important. We have identified T‐cell immunoglobulin and mucin‐domain containing‐3 (TIM‐3) as an LSC‐specific surface molecule in human myeloid malignancies and demonstrated its essential function in maintaining the self‐renewal ability of LSCs. TIM‐3 has been intensively investigated as a “coinhibitory” or “immune checkpoint” molecule of T cells. However, little is known about its distinct function in T cells and myeloid malignancies. In this review, we discuss the structure of TIM‐3 and its function in normal blood cells and LSCs, emphasizing the specific signaling pathways involved, as well as the therapeutic applications of TIM‐3 molecules in human myeloid malignancies. |
format | Online Article Text |
id | pubmed-8409405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84094052021-09-03 TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways Kikushige, Yoshikane Cancer Sci Review Articles Acute myeloid leukemia (AML) is hierarchically organized by self‐renewing leukemic stem cells (LSCs). LSCs originate from hematopoietic stem cells (HSCs) by acquiring multistep leukemogenic events. To specifically eradicate LSCs, while keeping normal HSCs intact, the discrimination of LSCs from HSCs is important. We have identified T‐cell immunoglobulin and mucin‐domain containing‐3 (TIM‐3) as an LSC‐specific surface molecule in human myeloid malignancies and demonstrated its essential function in maintaining the self‐renewal ability of LSCs. TIM‐3 has been intensively investigated as a “coinhibitory” or “immune checkpoint” molecule of T cells. However, little is known about its distinct function in T cells and myeloid malignancies. In this review, we discuss the structure of TIM‐3 and its function in normal blood cells and LSCs, emphasizing the specific signaling pathways involved, as well as the therapeutic applications of TIM‐3 molecules in human myeloid malignancies. John Wiley and Sons Inc. 2021-07-14 2021-09 /pmc/articles/PMC8409405/ /pubmed/34159709 http://dx.doi.org/10.1111/cas.15042 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Kikushige, Yoshikane TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways |
title | TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways |
title_full | TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways |
title_fullStr | TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways |
title_full_unstemmed | TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways |
title_short | TIM‐3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways |
title_sort | tim‐3 in normal and malignant hematopoiesis: structure, function, and signaling pathways |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409405/ https://www.ncbi.nlm.nih.gov/pubmed/34159709 http://dx.doi.org/10.1111/cas.15042 |
work_keys_str_mv | AT kikushigeyoshikane tim3innormalandmalignanthematopoiesisstructurefunctionandsignalingpathways |