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Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study
Evidence supporting the association of glycemic index (GI) and glycemic load (GL) with the risk of endometrial cancer is controversial and reports from Asia were limited. Therefore, we aimed to investigate the association in Japanese women. We evaluated 52 460 women in the Japan Public Health Center...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409411/ https://www.ncbi.nlm.nih.gov/pubmed/34053169 http://dx.doi.org/10.1111/cas.14997 |
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author | Watanabe, Yuya Katagiri, Ryoko Goto, Atsushi Shimazu, Taichi Yamaji, Taiki Sawada, Norie Iwasaki, Motoki Inoue, Manami Tsugane, Shoichiro |
author_facet | Watanabe, Yuya Katagiri, Ryoko Goto, Atsushi Shimazu, Taichi Yamaji, Taiki Sawada, Norie Iwasaki, Motoki Inoue, Manami Tsugane, Shoichiro |
author_sort | Watanabe, Yuya |
collection | PubMed |
description | Evidence supporting the association of glycemic index (GI) and glycemic load (GL) with the risk of endometrial cancer is controversial and reports from Asia were limited. Therefore, we aimed to investigate the association in Japanese women. We evaluated 52 460 women in the Japan Public Health Center‐based Prospective Study aged 45‐74 years who responded to the 5‐year follow‐up survey. GI and GL were calculated from a validated food frequency questionnaire, and the participants were divided into three groups by GI and GL. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with the Cox proportional hazard model adjusted for potential confounding factors. As a result, within 15.5 years of follow‐up, 166 new cases of endometrial cancer were identified. Compared with the lowest GI and GL tertile groups, the HR of the risk of endometrial cancer in the highest GI tertile group was 0.80 (95% CI, 0.53‐1.20; P(trend) = .33), and that of the highest GL tertile group was 0.79 (95% CI, 0.52‐1.19; P(trend) = .82). The results were unchanged after stratification by body mass index, coffee consumption, and history of diabetes. In conclusion, we did not find any significant association between GI and GL with the risk of endometrial cancer. Further research is required to clarify the association. |
format | Online Article Text |
id | pubmed-8409411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84094112021-09-03 Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study Watanabe, Yuya Katagiri, Ryoko Goto, Atsushi Shimazu, Taichi Yamaji, Taiki Sawada, Norie Iwasaki, Motoki Inoue, Manami Tsugane, Shoichiro Cancer Sci Original Articles Evidence supporting the association of glycemic index (GI) and glycemic load (GL) with the risk of endometrial cancer is controversial and reports from Asia were limited. Therefore, we aimed to investigate the association in Japanese women. We evaluated 52 460 women in the Japan Public Health Center‐based Prospective Study aged 45‐74 years who responded to the 5‐year follow‐up survey. GI and GL were calculated from a validated food frequency questionnaire, and the participants were divided into three groups by GI and GL. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with the Cox proportional hazard model adjusted for potential confounding factors. As a result, within 15.5 years of follow‐up, 166 new cases of endometrial cancer were identified. Compared with the lowest GI and GL tertile groups, the HR of the risk of endometrial cancer in the highest GI tertile group was 0.80 (95% CI, 0.53‐1.20; P(trend) = .33), and that of the highest GL tertile group was 0.79 (95% CI, 0.52‐1.19; P(trend) = .82). The results were unchanged after stratification by body mass index, coffee consumption, and history of diabetes. In conclusion, we did not find any significant association between GI and GL with the risk of endometrial cancer. Further research is required to clarify the association. John Wiley and Sons Inc. 2021-07-16 2021-09 /pmc/articles/PMC8409411/ /pubmed/34053169 http://dx.doi.org/10.1111/cas.14997 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Watanabe, Yuya Katagiri, Ryoko Goto, Atsushi Shimazu, Taichi Yamaji, Taiki Sawada, Norie Iwasaki, Motoki Inoue, Manami Tsugane, Shoichiro Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study |
title | Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study |
title_full | Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study |
title_fullStr | Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study |
title_full_unstemmed | Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study |
title_short | Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study |
title_sort | dietary glycemic index, glycemic load, and endometrial cancer risk: the japan public health center‐based prospective study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409411/ https://www.ncbi.nlm.nih.gov/pubmed/34053169 http://dx.doi.org/10.1111/cas.14997 |
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