Quadruple‐editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS‐mutated colorectal cancer cells

Mutated KRAS promotes the activation of the MAPK pathway and the progression of colorectal cancer (CRC) cells. Aberrant activation of the PI3K pathway strongly attenuates the efficacy of MAPK suppression in KRAS‐mutated CRC. The development of a novel strategy targeting a dual pathway is therefore h...

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Detalles Bibliográficos
Autores principales: Wang, Zaozao, Kang, Bin, Gao, Qianqian, Huang, Lei, Di, Jiabo, Fan, Yingcong, Yu, Jianhong, Jiang, Beihai, Gao, Feng, Wang, Dan, Sun, Haixi, Gu, Ying, Li, Jian, Su, Xiangqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409416/
https://www.ncbi.nlm.nih.gov/pubmed/34185934
http://dx.doi.org/10.1111/cas.15049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409416/
https://www.ncbi.nlm.nih.gov/pubmed/34185934
http://dx.doi.org/10.1111/cas.15049

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