Trametinib overcomes KRAS‐G12V–induced osimertinib resistance in a leptomeningeal carcinomatosis model of EGFR‐mutant lung cancer

Leptomeningeal carcinomatosis (LMC) occurs frequently in non–small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations and is associated with acquired resistance to EGFR tyrosine kinase inhibitors (EGFR‐TKIs). However, the mechanism by which LMC acquires resistance t...

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Detalles Bibliográficos
Autores principales: Fukuda, Koji, Otani, Sakiko, Takeuchi, Shinji, Arai, Sachiko, Nanjo, Shigeki, Tanimoto, Azusa, Nishiyama, Akihiro, Naoki, Katsuhiko, Yano, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409422/
https://www.ncbi.nlm.nih.gov/pubmed/34145930
http://dx.doi.org/10.1111/cas.15035

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