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Direct decarboxylation of ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation

DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA (cytosine-5)-methyltransferases (DNMTs) are responsible for the generation and maintenance of 5mC in genomes. Active demet...

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Detalles Bibliográficos
Autores principales:	Feng, Yang, Chen, Juan-Juan, Xie, Neng-Bin, Ding, Jiang-Hui, You, Xue-Jiao, Tao, Wan-Bing, Zhang, Xiaoxue, Yi, Chengqi, Zhou, Xiang, Yuan, Bi-Feng, Feng, Yu-Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409474/ https://www.ncbi.nlm.nih.gov/pubmed/34567494 http://dx.doi.org/10.1039/d1sc02161c

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