The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice

Cancer therapy can be associated with short- and long-term cardiac dysfunction. Patients with cancer often exhibit therapy-related clonal hematopoiesis (t-CH), an aggressive form of clonal hematopoiesis that can result from somatic mutations in genes encoding regulators of the DNA-damage response (D...

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Detalles Bibliográficos
Autores principales: Yura, Yoshimitsu, Miura-Yura, Emiri, Katanasaka, Yasufumi, Min, Kyung-Duk, Chavkin, Nicholas, Polizio, Ariel H., Ogawa, Hayato, Horitani, Keita, Doviak, Heather, Evans, Megan A., Sano, Miho, Wang, Ying, Boroviak, Katharina, Philippos, George, Domingues, Ana Filipa, Vassiliou, George, Sano, Soichi, Walsh, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409899/
https://www.ncbi.nlm.nih.gov/pubmed/34315245
http://dx.doi.org/10.1161/CIRCRESAHA.121.319314

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