Cargando…

Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors

In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ji-Yul, Ki, Dae-Won, Lee, Yoon-Ju, Ha, Lee Su, Woo, E-Eum, Lee, In-Kyoung, Yun, Bong-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409934/
https://www.ncbi.nlm.nih.gov/pubmed/34512086
http://dx.doi.org/10.1080/12298093.2021.1924926
_version_ 1783747062041411584
author Kim, Ji-Yul
Ki, Dae-Won
Lee, Yoon-Ju
Ha, Lee Su
Woo, E-Eum
Lee, In-Kyoung
Yun, Bong-Sik
author_facet Kim, Ji-Yul
Ki, Dae-Won
Lee, Yoon-Ju
Ha, Lee Su
Woo, E-Eum
Lee, In-Kyoung
Yun, Bong-Sik
author_sort Kim, Ji-Yul
collection PubMed
description In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C(18) cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A–C (1-3).
format Online
Article
Text
id pubmed-8409934
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-84099342021-09-10 Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors Kim, Ji-Yul Ki, Dae-Won Lee, Yoon-Ju Ha, Lee Su Woo, E-Eum Lee, In-Kyoung Yun, Bong-Sik Mycobiology Research Note In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C(18) cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A–C (1-3). Taylor & Francis 2021-05-13 /pmc/articles/PMC8409934/ /pubmed/34512086 http://dx.doi.org/10.1080/12298093.2021.1924926 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Korean Society of Mycology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Kim, Ji-Yul
Ki, Dae-Won
Lee, Yoon-Ju
Ha, Lee Su
Woo, E-Eum
Lee, In-Kyoung
Yun, Bong-Sik
Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_full Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_fullStr Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_full_unstemmed Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_short Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_sort consoramides a–c, new zwitterionic alkaloids from the fungus irpex consors
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409934/
https://www.ncbi.nlm.nih.gov/pubmed/34512086
http://dx.doi.org/10.1080/12298093.2021.1924926
work_keys_str_mv AT kimjiyul consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
AT kidaewon consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
AT leeyoonju consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
AT haleesu consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
AT wooeeum consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
AT leeinkyoung consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
AT yunbongsik consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors