Cargando…

Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus

Obesity is an important risk factor for the development of diseases including diabetes, hypertension, and cardiovascular disease. However, few reports have investigated the relationships between these obesity-related indices and diabetic nephropathy. The aim of this study was to evaluate association...

Descripción completa

Detalles Bibliográficos
Autores principales: Ou, Yu-Lun, Lee, Mei-Yueh, Lin, I-Ting, Wen, Wei-Lun, Hsu, Wei-Hao, Chen, Szu-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409948/
https://www.ncbi.nlm.nih.gov/pubmed/34461808
http://dx.doi.org/10.1080/0886022X.2021.1969247
_version_ 1783747065397903360
author Ou, Yu-Lun
Lee, Mei-Yueh
Lin, I-Ting
Wen, Wei-Lun
Hsu, Wei-Hao
Chen, Szu-Chia
author_facet Ou, Yu-Lun
Lee, Mei-Yueh
Lin, I-Ting
Wen, Wei-Lun
Hsu, Wei-Hao
Chen, Szu-Chia
author_sort Ou, Yu-Lun
collection PubMed
description Obesity is an important risk factor for the development of diseases including diabetes, hypertension, and cardiovascular disease. However, few reports have investigated the relationships between these obesity-related indices and diabetic nephropathy. The aim of this study was to evaluate associations between obesity-related markers with albuminuria and advanced kidney disease in patients with type 2 diabetes mellitus (DM). Obesity-related indices including body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CI), lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), body shape index (BSI), and triglyceride glucose (TyG) index were measured. Albuminuria was defined as a urine albumin/creatinine ratio of ≥30 mg/g. Advanced kidney disease was defined as an estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m(2). A total of 1872 patients with type 2 DM (mean age 64.0 ± 11.3 years, 809 males and 1063 females) were enrolled. In multivariable analysis, 11 high obesity-related indices (BMI, WHR, WHtR, LAP, BRI, CI, VAI, BAI, AVI, ABSI, and TyG index) were significantly associated with albuminuria. In addition, high BMI, WHR, WHtR, LAP, BRI, CI, VAI, and AVI were significantly associated with eGFR <30 ml/min/1.73 m(2). The results of this study showed that various obesity-related indices were significantly associated with albuminuria and advanced kidney disease in patients with type 2 DM. Screening may be considered in public health programs to recognize and take appropriate steps to prevent subsequent complications.
format Online
Article
Text
id pubmed-8409948
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-84099482021-09-02 Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus Ou, Yu-Lun Lee, Mei-Yueh Lin, I-Ting Wen, Wei-Lun Hsu, Wei-Hao Chen, Szu-Chia Ren Fail Clinical Study Obesity is an important risk factor for the development of diseases including diabetes, hypertension, and cardiovascular disease. However, few reports have investigated the relationships between these obesity-related indices and diabetic nephropathy. The aim of this study was to evaluate associations between obesity-related markers with albuminuria and advanced kidney disease in patients with type 2 diabetes mellitus (DM). Obesity-related indices including body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CI), lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), body shape index (BSI), and triglyceride glucose (TyG) index were measured. Albuminuria was defined as a urine albumin/creatinine ratio of ≥30 mg/g. Advanced kidney disease was defined as an estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m(2). A total of 1872 patients with type 2 DM (mean age 64.0 ± 11.3 years, 809 males and 1063 females) were enrolled. In multivariable analysis, 11 high obesity-related indices (BMI, WHR, WHtR, LAP, BRI, CI, VAI, BAI, AVI, ABSI, and TyG index) were significantly associated with albuminuria. In addition, high BMI, WHR, WHtR, LAP, BRI, CI, VAI, and AVI were significantly associated with eGFR <30 ml/min/1.73 m(2). The results of this study showed that various obesity-related indices were significantly associated with albuminuria and advanced kidney disease in patients with type 2 DM. Screening may be considered in public health programs to recognize and take appropriate steps to prevent subsequent complications. Taylor & Francis 2021-08-30 /pmc/articles/PMC8409948/ /pubmed/34461808 http://dx.doi.org/10.1080/0886022X.2021.1969247 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Ou, Yu-Lun
Lee, Mei-Yueh
Lin, I-Ting
Wen, Wei-Lun
Hsu, Wei-Hao
Chen, Szu-Chia
Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
title Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
title_full Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
title_fullStr Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
title_full_unstemmed Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
title_short Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
title_sort obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409948/
https://www.ncbi.nlm.nih.gov/pubmed/34461808
http://dx.doi.org/10.1080/0886022X.2021.1969247
work_keys_str_mv AT ouyulun obesityrelatedindicesareassociatedwithalbuminuriaandadvancedkidneydiseaseintype2diabetesmellitus
AT leemeiyueh obesityrelatedindicesareassociatedwithalbuminuriaandadvancedkidneydiseaseintype2diabetesmellitus
AT liniting obesityrelatedindicesareassociatedwithalbuminuriaandadvancedkidneydiseaseintype2diabetesmellitus
AT wenweilun obesityrelatedindicesareassociatedwithalbuminuriaandadvancedkidneydiseaseintype2diabetesmellitus
AT hsuweihao obesityrelatedindicesareassociatedwithalbuminuriaandadvancedkidneydiseaseintype2diabetesmellitus
AT chenszuchia obesityrelatedindicesareassociatedwithalbuminuriaandadvancedkidneydiseaseintype2diabetesmellitus