Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

The α-ketoglutarate–dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues. Although PHD3 has been reported to influence cancer cell metabolism and liver insulin sensitivity, relatively little is known about the effec...

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Detalles Bibliográficos
Autores principales: Nasteska, Daniela, Cuozzo, Federica, Viloria, Katrina, Johnson, Elspeth M., Thakker, Alpesh, Bany Bakar, Rula, Westbrook, Rebecca L., Barlow, Jonathan P., Hoang, Monica, Joseph, Jamie W., Lavery, Gareth G., Akerman, Ildem, Cantley, James, Hodson, Leanne, Tennant, Daniel A., Hodson, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409982/
https://www.ncbi.nlm.nih.gov/pubmed/34264866
http://dx.doi.org/10.1172/jci.insight.140288

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