Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias

Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular level is still elusive, given the diversity of MCPH genes and lack of compar...

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Detalles Bibliográficos
Autores principales: González-Martínez, José, Cwetsch, Andrzej W., Martínez-Alonso, Diego, López-Sainz, Luis R., Almagro, Jorge, Melati, Anna, Gómez, Jesús, Pérez-Martínez, Manuel, Megías, Diego, Boskovic, Jasminka, Gilabert-Juan, Javier, Graña-Castro, Osvaldo, Pierani, Alessandra, Behrens, Axel, Ortega, Sagrario, Malumbres, Marcos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409993/
https://www.ncbi.nlm.nih.gov/pubmed/34237032
http://dx.doi.org/10.1172/jci.insight.146364

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