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Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting
OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were ass...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410005/ https://www.ncbi.nlm.nih.gov/pubmed/33506862 http://dx.doi.org/10.1093/rheumatology/keab067 |
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author | Swain, Subhashisa Coupland, Carol Mallen, Christian Kuo, Chang Fu Sarmanova, Aliya Bierma-Zeinstra, Sita M A Englund, Martin Prieto-Alhambra, Daniel Doherty, Michael Zhang, Weiya |
author_facet | Swain, Subhashisa Coupland, Carol Mallen, Christian Kuo, Chang Fu Sarmanova, Aliya Bierma-Zeinstra, Sita M A Englund, Martin Prieto-Alhambra, Daniel Doherty, Michael Zhang, Weiya |
author_sort | Swain, Subhashisa |
collection | PubMed |
description | OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidities (two or more comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aORs) and hazard ratios (aHRs), respectively. RESULTS: During 1997–2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to and following the diagnosis of OA and 2 (dementia and systemic lupus erythematosus) were associated with OA only following the diagnosis of OA. People with OA had a higher risk of developing heart failure [aHR 1.63 (95% CI 1.56, 1.71)], dementia [aHR 1.62 (95% CI 1.56, 1.68)], liver diseases [aHR 1.51 (95% CI 1.37, 1.67)], irritable bowel syndrome [aHR 1.51 (95% CI 1.45, 1.58)], gastrointestinal bleeding [aHR 1.49 (95% CI 1.39, 1.59)], 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95% CI 1.69, 1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95% CI 1.28, 1.30). CONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed. |
format | Online Article Text |
id | pubmed-8410005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84100052021-09-02 Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting Swain, Subhashisa Coupland, Carol Mallen, Christian Kuo, Chang Fu Sarmanova, Aliya Bierma-Zeinstra, Sita M A Englund, Martin Prieto-Alhambra, Daniel Doherty, Michael Zhang, Weiya Rheumatology (Oxford) Clinical Science OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidities (two or more comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aORs) and hazard ratios (aHRs), respectively. RESULTS: During 1997–2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to and following the diagnosis of OA and 2 (dementia and systemic lupus erythematosus) were associated with OA only following the diagnosis of OA. People with OA had a higher risk of developing heart failure [aHR 1.63 (95% CI 1.56, 1.71)], dementia [aHR 1.62 (95% CI 1.56, 1.68)], liver diseases [aHR 1.51 (95% CI 1.37, 1.67)], irritable bowel syndrome [aHR 1.51 (95% CI 1.45, 1.58)], gastrointestinal bleeding [aHR 1.49 (95% CI 1.39, 1.59)], 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95% CI 1.69, 1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95% CI 1.28, 1.30). CONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed. Oxford University Press 2021-03-01 /pmc/articles/PMC8410005/ /pubmed/33506862 http://dx.doi.org/10.1093/rheumatology/keab067 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Science Swain, Subhashisa Coupland, Carol Mallen, Christian Kuo, Chang Fu Sarmanova, Aliya Bierma-Zeinstra, Sita M A Englund, Martin Prieto-Alhambra, Daniel Doherty, Michael Zhang, Weiya Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting |
title | Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting |
title_full | Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting |
title_fullStr | Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting |
title_full_unstemmed | Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting |
title_short | Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting |
title_sort | temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the uk primary care setting |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410005/ https://www.ncbi.nlm.nih.gov/pubmed/33506862 http://dx.doi.org/10.1093/rheumatology/keab067 |
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