CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy

Targeting T cell malignancies with universal CD7-targeting chimeric antigen receptor T cells (UCART7) can lead to profound immune deficiency due to loss of normal T and NK cells. While a small population of endogenous CD7(–) T cells exists, these cells are unlikely to be able to repopulate the entir...

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Detalles Bibliográficos
Autores principales: Kim, Miriam Y., Cooper, Matthew L., Jacobs, Miriam T., Ritchey, Julie K., Hollaway, Julia, Fehniger, Todd A., DiPersio, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410010/
https://www.ncbi.nlm.nih.gov/pubmed/34423790
http://dx.doi.org/10.1172/jci.insight.149819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410010/
https://www.ncbi.nlm.nih.gov/pubmed/34423790
http://dx.doi.org/10.1172/jci.insight.149819

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