Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation

Iron is an essential nutrient for mammals as well as for pathogens. Inflammation-driven changes in systemic and cellular iron homeostasis are central for host-mediated antimicrobial strategies. Here, we studied the role of the iron storage protein ferritin H (FTH) for the control of infections with...

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Detalles Bibliográficos
Autores principales: Haschka, David, Tymoszuk, Piotr, Petzer, Verena, Hilbe, Richard, Heeke, Simon, Dichtl, Stefanie, Skvortsov, Sergej, Demetz, Egon, Berger, Sylvia, Seifert, Markus, Mitterstiller, Anna-Maria, Moser, Patrizia, Bumann, Dirk, Nairz, Manfred, Theurl, Igor, Weiss, Guenter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410025/
https://www.ncbi.nlm.nih.gov/pubmed/34236052
http://dx.doi.org/10.1172/jci.insight.141760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410025/
https://www.ncbi.nlm.nih.gov/pubmed/34236052
http://dx.doi.org/10.1172/jci.insight.141760

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