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Extracellular CIRP activates STING to exacerbate hemorrhagic shock

Stimulator of IFN genes (STING) activates TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) to produce type I IFNs. Extracellular cold-inducible RNA-binding protein (eCIRP) is released from cells during hemorrhagic shock (HS). We hypothesized that eCIRP activates STING to induce inflam...

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Detalles Bibliográficos
Autores principales:	Chen, Kehong, Cagliani, Joaquin, Aziz, Monowar, Tan, Chuyi, Brenner, Max, Wang, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410031/ https://www.ncbi.nlm.nih.gov/pubmed/34291735 http://dx.doi.org/10.1172/jci.insight.143715

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