mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury

The acute respiratory distress syndrome (ARDS) is a highly lethal condition that impairs lung function and causes respiratory failure. Mechanical ventilation (MV) maintains gas exchange in patients with ARDS but exposes lung cells to physical forces that exacerbate injury. Our data demonstrate that...

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Detalles Bibliográficos
Autores principales: Lee, Hyunwook, Fei, Qinqin, Streicher, Adam, Zhang, Wenjuan, Isabelle, Colleen, Patel, Pragi, Lam, Hilaire C., Arciniegas-Rubio, Antonio, Pinilla-Vera, Miguel, Amador-Munoz, Diana P., Barragan-Bradford, Diana, Higuera-Moreno, Angelica, Putman, Rachel K., Sholl, Lynette M., Henske, Elizabeth P., Bobba, Christopher M., Higuita-Castro, Natalia, Shalosky, Emily M., Hite, R. Duncan, Christman, John W., Ghadiali, Samir N., Baron, Rebecca M., Englert, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410036/
https://www.ncbi.nlm.nih.gov/pubmed/34138757
http://dx.doi.org/10.1172/jci.insight.137708

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