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Monoallelic IRF5 deficiency in B cells prevents murine lupus

Gain-of-function polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are associated with an increased risk of developing systemic lupus erythematosus. However, the IRF5-expressing cell type(s) responsible for lupus pathogenesis in vivo is not known. We now show that monoallelic...

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Detalles Bibliográficos
Autores principales:	Pellerin, Alex, Yasuda, Kei, Cohen-Bucay, Abraham, Sandra, Vanessa, Shukla, Prachi, Jr, Barry K. Horne, Nündel, Kerstin, Viglianti, Gregory A., Xie, Yao, Klein, Ulf, Tan, Ying, Bonegio, Ramon G., Rifkin, Ian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410043/ https://www.ncbi.nlm.nih.gov/pubmed/34197340 http://dx.doi.org/10.1172/jci.insight.141395

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