Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway

The mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of acetaldehyde and endogenous lipid aldehydes. Approximately 40% of East Asians, accounting for 8% of the human population, carry the E504K mutation in ALDH2 that leads to accumulation of toxic reactive aldehydes...

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Detalles Bibliográficos
Autores principales: Xu, Tonghui, Guo, Jialin, Wei, Maozeng, Wang, Jiali, Yang, Kehui, Pan, Chang, Pang, Jiaojiao, Xue, Li, Yuan, Qiuhuan, Xue, Mengyang, Zhang, Jian, Sang, Wentao, Jiang, Tangxing, Chen, Yuguo, Xu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410052/
https://www.ncbi.nlm.nih.gov/pubmed/34228649
http://dx.doi.org/10.1172/jci.insight.138183

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