Cargando…

Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors

SCN2A, encoding the neuronal voltage-gated Na(+) channel Na(V)1.2, is one of the most commonly affected loci linked to autism spectrum disorders (ASDs). Most ASD-associated mutations in SCN2A are loss-of-function mutations, but studies examining how such mutations affect neuronal function and whethe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hong-Gang, Bavley, Charlotte C., Li, Anfei, Jones, Rebecca M., Hackett, Jonathan, Bayleyen, Yared, Lee, Francis S., Rajadhyaksha, Anjali M., Pitt, Geoffrey S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410058/ https://www.ncbi.nlm.nih.gov/pubmed/34156984 http://dx.doi.org/10.1172/jci.insight.150698

Ejemplares similares

The functional organization of excitatory synaptic input to place cells
por: Adoff, Michael D., et al.
Publicado: (2021)

Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
por: He, Hai-yan, et al.
Publicado: (2018)

Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions
por: Hedrick, Tristan P., et al.
Publicado: (2017)

Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input
por: Vervaeke, Koen, et al.
Publicado: (2010)

Ca(v)1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway
por: Bavley, Charlotte C., et al.
Publicado: (2017)

Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons
por: Xiao, Lei, et al.
Publicado: (2018)

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons
por: Ju, Niansheng, et al.
Publicado: (2020)

Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model
por: Zhou, Xujiao, et al.
Publicado: (2019)

Adenosine Inhibits the Excitatory Synaptic Inputs to Basal Forebrain Cholinergic, GABAergic, and Parvalbumin Neurons in Mice
por: Yang, Chun, et al.
Publicado: (2013)

Spatial organization of excitatory synaptic inputs to layer 4 neurons in mouse primary auditory cortex
por: Kratz, Megan B., et al.
Publicado: (2015)

On how correlations between excitatory and inhibitory synaptic inputs maximize the information rate of neuronal firing
por: Puzerey, Pavel A., et al.
Publicado: (2014)

Input-selective adenosine A(1) receptor-mediated synaptic depression of excitatory transmission in dorsal striatum
por: Fritz, Brandon M., et al.
Publicado: (2021)

Endomorphin-2 Decreases Excitatory Synaptic Transmission in the Spinal Ventral Horn of the Rat
por: Wu, Zhen-Yu, et al.
Publicado: (2017)

Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory
por: Shin, Wangyong, et al.
Publicado: (2019)

Properties and modulation of excitatory inputs to the locus coeruleus
por: Barcomb, Kelsey, et al.
Publicado: (2022)

Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A )receptor chloride channels
por: Ying, Shui-Wang, et al.
Publicado: (2005)

The principal neurons of the medial nucleus of the trapezoid body and NG2(+) glial cells receive coordinated excitatory synaptic input
por: Müller, Jochen, et al.
Publicado: (2009)

Inferring trial-to-trial excitatory and inhibitory synaptic inputs from membrane potential using Gaussian mixture Kalman filtering
por: Lankarany, M., et al.
Publicado: (2013)

Oxytocin Cells in the Supraoptic Nucleus Receive Excitatory Synaptic Inputs from the Contralateral Supraoptic and Paraventricular Nuclei in the Lactating Rat
por: HONDA, Kazumasa, et al.
Publicado: (2013)

SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes
por: van Hugte, Eline J H, et al.
Publicado: (2023)

Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons via neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain
por: Wang, Lei, et al.
Publicado: (2022)

No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons123
por: Willett, Jaime A., et al.
Publicado: (2016)

Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix
por: Hayani, Hussam, et al.
Publicado: (2018)

Neddylation regulates excitatory synaptic transmission and plasticity
por: Brockmann, Marisa M., et al.
Publicado: (2019)

Modification of the synaptic cleft under excitatory conditions
por: Tao-Cheng, Jung-Hwa, et al.
Publicado: (2023)

Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc
por: Kalappa, Bopanna I., et al.
Publicado: (2017)

How inhibitory and excitatory inputs gate output of the inferior olive
por: Loyola, Sebastián, et al.
Publicado: (2023)

Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders
por: Nava, Caroline, et al.
Publicado: (2015)

Molecular and cellular determinants of motor asymmetry in zebrafish
por: Horstick, Eric J., et al.
Publicado: (2020)

Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52
por: Hull, Jacob M., et al.
Publicado: (2020)

Irregular Persistent Activity Induced by Synaptic Excitatory Feedback
por: Barbieri, Francesca, et al.
Publicado: (2007)

Irregular persistent activity induced by synaptic excitatory feedback
por: Barbieri, Francesca, et al.
Publicado: (2007)

Excitatory to inhibitory connectivity shaped by synaptic and homeostatic plasticity
por: Clopath, Claudia, et al.
Publicado: (2015)

Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain
por: Lorenz-Guertin, Joshua M., et al.
Publicado: (2023)

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
por: Sacai, Hiroaki, et al.
Publicado: (2020)

Cannabinoids attenuate hippocampal gamma oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells
por: Holderith, Noémi, et al.
Publicado: (2011)

Preserved Excitatory-Inhibitory Balance of Cortical Synaptic Inputs following Deprived Eye Stimulation after a Saturating Period of Monocular Deprivation in Rats
por: Iurilli, Giuliano, et al.
Publicado: (2013)

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities
por: Yoo, Taesun, et al.
Publicado: (2018)

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch
por: Kanehisa, Kensho, et al.
Publicado: (2022)

Rapid generation of hypomorphic mutations
por: Arthur, Laura L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1asr2lirvljh7g9jj3o0c92nub