Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism

Estrogen-related receptor γ (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls Tregs through mitochondria homeostasis. Esrrg deficiency impaired the maintenance and function of Tregs, leading to global T cell activation and autoimmuni...

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Detalles Bibliográficos
Autores principales: Li, Wei, Gong, Minghao, Park, Yuk Pheel, Elshikha, Ahmed S., Choi, Seung-Chul, Brown, Josephine, Kanda, Nathalie, Yeh, Wen-I, Peters, Leeana, Titov, Anton A., Teng, Xiangyu, Brusko, Todd M., Morel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410062/
https://www.ncbi.nlm.nih.gov/pubmed/34156979
http://dx.doi.org/10.1172/jci.insight.143540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410062/
https://www.ncbi.nlm.nih.gov/pubmed/34156979
http://dx.doi.org/10.1172/jci.insight.143540

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