Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition

We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hypertension (PAH). Furthermore, recombinant HERV-K...

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Detalles Bibliográficos
Autores principales: Otsuki, Shoichiro, Saito, Toshie, Taylor, Shalina, Li, Dan, Moonen, Jan-Renier, Marciano, David P., Harper, Rebecca L., Cao, Aiqin, Wang, Lingli, Ariza, Maria E., Rabinovitch, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410063/
https://www.ncbi.nlm.nih.gov/pubmed/34185707
http://dx.doi.org/10.1172/jci.insight.146416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410063/
https://www.ncbi.nlm.nih.gov/pubmed/34185707
http://dx.doi.org/10.1172/jci.insight.146416

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