Cargando…

Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition

We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hypertension (PAH). Furthermore, recombinant HERV-K...

Descripción completa

Detalles Bibliográficos
Autores principales:	Otsuki, Shoichiro, Saito, Toshie, Taylor, Shalina, Li, Dan, Moonen, Jan-Renier, Marciano, David P., Harper, Rebecca L., Cao, Aiqin, Wang, Lingli, Ariza, Maria E., Rabinovitch, Marlene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410063/ https://www.ncbi.nlm.nih.gov/pubmed/34185707 http://dx.doi.org/10.1172/jci.insight.146416

Ejemplares similares

Viral dUTPases: Modulators of Innate Immunity
por: Ariza, Maria Eugenia, et al.
Publicado: (2022)

Life without dUTPase
por: Kerepesi, Csaba, et al.
Publicado: (2016)

The dUTPase Enzyme Is Essential in Mycobacterium smegmatis
por: Pecsi, Ildiko, et al.
Publicado: (2012)

The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein
por: Voronin, Nickolay, et al.
Publicado: (2014)

Homologous Recombination Is Stimulated by a Decrease in dUTPase in Arabidopsis
por: Dubois, Emeline, et al.
Publicado: (2011)

dUTPase: the frequently overlooked enzyme encoded by many retroviruses
por: Hizi, Amnon, et al.
Publicado: (2015)

Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis
por: Alam, Md. Shahanoor, et al.
Publicado: (2019)

dUTPase inhibition augments replication defects of 5-Fluorouracil
por: Hagenkort, Anna, et al.
Publicado: (2017)

EBV dUTPase: A Novel Modulator of Inflammation and the Tumor Microenvironment in EBV-Associated Malignancies
por: Williams, Marshall V., et al.
Publicado: (2023)

Protective Effect of Human Endogenous Retrovirus K dUTPase Variants on Psoriasis Susceptibility
por: Lai, Olivia Y., et al.
Publicado: (2012)

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
por: Németh-Pongrácz, Veronika, et al.
Publicado: (2007)

dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae
por: Guillet, Marie, et al.
Publicado: (2006)

Erratum to: dUTPase: the frequently overlooked enzyme encoded by many retroviruses
por: Hizi, Amnon, et al.
Publicado: (2015)

Human herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity
por: Ariza, Maria Eugenia, et al.
Publicado: (2014)

Structural model of human dUTPase in complex with a novel proteinaceous inhibitor
por: Nyíri, Kinga, et al.
Publicado: (2018)

Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization
por: Donderis, Jorge, et al.
Publicado: (2017)

Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus
por: Chia, Catherine P., et al.
Publicado: (2020)

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease
por: Williams, Marshall V., et al.
Publicado: (2016)

Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
por: Pecsi, Ildiko, et al.
Publicado: (2010)

The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase
por: Benedek, András, et al.
Publicado: (2017)

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies
por: Zhang, Shuai, et al.
Publicado: (2021)

Molecular Characterization of UL50 (dUTPase) Gene of Bovine Herpes Virus 1
por: Shahin, Farzana, et al.
Publicado: (2023)

EBV Positive Diffuse Large B Cell Lymphoma and Chronic Lymphocytic Leukemia Patients Exhibit Increased Anti-dUTPase Antibodies
por: Williams, Marshall, et al.
Publicado: (2018)

Examination of control asymptomatic cohorts reveals heightened anti‐EBV and HHV‐6 A/B dUTPase antibodies in the aging populations
por: Alharshawi, Khaled, et al.
Publicado: (2022)

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitorD9331
por: Webley, S D, et al.
Publicado: (2000)

Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer
por: Kawahara, A, et al.
Publicado: (2009)

Calpain-Catalyzed Proteolysis of Human dUTPase Specifically Removes the Nuclear Localization Signal Peptide
por: Bozóky, Zoltán, et al.
Publicado: (2011)

The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibition
por: Benedek, András, et al.
Publicado: (2019)

Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes
por: Hirmondo, Rita, et al.
Publicado: (2017)

The Bacteriophage–Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases
por: Sanz-Frasquet, Carla, et al.
Publicado: (2023)

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension
por: Isobe, Sarasa, et al.
Publicado: (2023)

CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality
por: Pálinkás, Hajnalka Laura, et al.
Publicado: (2019)

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity
por: Pérez-Moreno, Guiomar, et al.
Publicado: (2019)

Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target
por: Li, Changyao, et al.
Publicado: (2019)

EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing T(FH) cell differentiation and extrafollicular activities
por: Cox, Brandon S., et al.
Publicado: (2022)

The Anti-interferon Activity of Conserved Viral dUTPase ORF54 is Essential for an Effective MHV-68 Infection
por: Leang, Ronika Sitapara, et al.
Publicado: (2011)

Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()
por: Hampton, Shahienaz E., et al.
Publicado: (2013)

Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80α dUTPase
por: Alite, Christian, et al.
Publicado: (2017)

Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development
por: Liang, Rui, et al.
Publicado: (2020)

Epstein-Barr Virus Encoded dUTPase Containing Exosomes Modulate Innate and Adaptive Immune Responses in Human Dendritic Cells and Peripheral Blood Mononuclear Cells
por: Ariza, Maria Eugenia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jrsur5i2iqkftnbv742lipqqkl