TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response

Therapy-related clonal hematopoiesis (t-CH) is often observed in cancer survivors. This form of clonal hematopoiesis typically involves somatic mutations in driver genes that encode components of the DNA damage response and confer hematopoietic stem and progenitor cells (HSPCs) with resistance to th...

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Detalles Bibliográficos
Autores principales: Sano, Soichi, Wang, Ying, Ogawa, Hayato, Horitani, Keita, Sano, Miho, Polizio, Ariel H., Kour, Anupreet, Yura, Yoshimitsu, Doviak, Heather, Walsh, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410064/
https://www.ncbi.nlm.nih.gov/pubmed/34236050
http://dx.doi.org/10.1172/jci.insight.146076

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