ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody

The blood-brain barrier (BBB) prevents antibodies from penetrating the CNS and limits conventional antibody-based approaches to brain tumors. We now show that ENT2, a transporter that regulates nucleoside flux at the BBB, may offer an unexpected path to circumventing this barrier to allow targeting...

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Detalles Bibliográficos
Autores principales: Rattray, Zahra, Deng, Gang, Zhang, Shenqi, Shirali, Anupama, May, Christopher K., Chen, Xiaoyong, Cuffari, Benedette J., Liu, Jun, Zou, Pan, Rattray, Nicholas J.W., Johnson, Caroline H., Dubljevic, Valentina, Campbell, James A., Huttner, Anita, Baehring, Joachim M., Zhou, Jiangbing, Hansen, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410084/
https://www.ncbi.nlm.nih.gov/pubmed/34128837
http://dx.doi.org/10.1172/jci.insight.145875

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