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Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy
The base order-dependent component of folding energy has revealed a highly conserved region in HIV-1 genomes that associates with RNA structure. This corresponds to a packaging signal that is recognized by the nucleocapsid domain of the Gag polyprotein. Long viewed as a potential HIV-1 "Achille...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410225/ https://www.ncbi.nlm.nih.gov/pubmed/34500325 http://dx.doi.org/10.1016/j.compbiolchem.2021.107570 |
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author | Zhang, Chiyu Forsdyke, Donald R. |
author_facet | Zhang, Chiyu Forsdyke, Donald R. |
author_sort | Zhang, Chiyu |
collection | PubMed |
description | The base order-dependent component of folding energy has revealed a highly conserved region in HIV-1 genomes that associates with RNA structure. This corresponds to a packaging signal that is recognized by the nucleocapsid domain of the Gag polyprotein. Long viewed as a potential HIV-1 "Achilles heel," the signal can be targeted by a new antiviral compound. Although SARS-CoV-2 differs in many respects from HIV-1, the same technology displays regions with a high base order-dependent folding energy component, which are also highly conserved. This indicates structural invariance (SI) sustained by natural selection. While the regions are often also protein-encoding (e. g. NSP3, ORF3a), we suggest that their nucleic acid level functions can be considered potential "Achilles heels" for SARS-CoV-2, perhaps susceptible to therapies like those envisaged for AIDS. The ribosomal frameshifting element scored well, but higher SI scores were obtained in other regions, including those encoding NSP13 and the nucleocapsid (N) protein. |
format | Online Article Text |
id | pubmed-8410225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84102252021-09-02 Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy Zhang, Chiyu Forsdyke, Donald R. Comput Biol Chem Article The base order-dependent component of folding energy has revealed a highly conserved region in HIV-1 genomes that associates with RNA structure. This corresponds to a packaging signal that is recognized by the nucleocapsid domain of the Gag polyprotein. Long viewed as a potential HIV-1 "Achilles heel," the signal can be targeted by a new antiviral compound. Although SARS-CoV-2 differs in many respects from HIV-1, the same technology displays regions with a high base order-dependent folding energy component, which are also highly conserved. This indicates structural invariance (SI) sustained by natural selection. While the regions are often also protein-encoding (e. g. NSP3, ORF3a), we suggest that their nucleic acid level functions can be considered potential "Achilles heels" for SARS-CoV-2, perhaps susceptible to therapies like those envisaged for AIDS. The ribosomal frameshifting element scored well, but higher SI scores were obtained in other regions, including those encoding NSP13 and the nucleocapsid (N) protein. Elsevier Ltd. 2021-10 2021-09-02 /pmc/articles/PMC8410225/ /pubmed/34500325 http://dx.doi.org/10.1016/j.compbiolchem.2021.107570 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zhang, Chiyu Forsdyke, Donald R. Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |
title | Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |
title_full | Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |
title_fullStr | Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |
title_full_unstemmed | Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |
title_short | Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |
title_sort | potential achilles heels of sars-cov-2 are best displayed by the base order-dependent component of rna folding energy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410225/ https://www.ncbi.nlm.nih.gov/pubmed/34500325 http://dx.doi.org/10.1016/j.compbiolchem.2021.107570 |
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