Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis

This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit Cα (PP2Acα, encoded by PPP2CA) and methyltransferase-like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochem...

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Detalles Bibliográficos
Autores principales: Cheng, Zhaoxiang, Gao, Shan, Liang, Xiaojie, Lian, Chao, Chen, Jianquan, Fang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410407/
https://www.ncbi.nlm.nih.gov/pubmed/34485508
http://dx.doi.org/10.1155/2021/1015293
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author Cheng, Zhaoxiang
Gao, Shan
Liang, Xiaojie
Lian, Chao
Chen, Jianquan
Fang, Chao
author_facet Cheng, Zhaoxiang
Gao, Shan
Liang, Xiaojie
Lian, Chao
Chen, Jianquan
Fang, Chao
author_sort Cheng, Zhaoxiang
collection PubMed
description This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit Cα (PP2Acα, encoded by PPP2CA) and methyltransferase-like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochemistry results, we found that abnormal PP2Acα and METTL3 levels were closely related to the malignant progression of GC. To explore the internal connection between PP2Acα and METTL3 in the progression of GC, we carried out cellular and molecular experiments and finally proved that PP2Acα inhibition can upregulate METTL3 levels by activating ATM activity, thereby promoting the malignant progression of GC.
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spelling pubmed-84104072021-09-02 Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis Cheng, Zhaoxiang Gao, Shan Liang, Xiaojie Lian, Chao Chen, Jianquan Fang, Chao Biomed Res Int Research Article This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit Cα (PP2Acα, encoded by PPP2CA) and methyltransferase-like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochemistry results, we found that abnormal PP2Acα and METTL3 levels were closely related to the malignant progression of GC. To explore the internal connection between PP2Acα and METTL3 in the progression of GC, we carried out cellular and molecular experiments and finally proved that PP2Acα inhibition can upregulate METTL3 levels by activating ATM activity, thereby promoting the malignant progression of GC. Hindawi 2021-08-24 /pmc/articles/PMC8410407/ /pubmed/34485508 http://dx.doi.org/10.1155/2021/1015293 Text en Copyright © 2021 Zhaoxiang Cheng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cheng, Zhaoxiang
Gao, Shan
Liang, Xiaojie
Lian, Chao
Chen, Jianquan
Fang, Chao
Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
title Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
title_full Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
title_fullStr Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
title_full_unstemmed Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
title_short Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
title_sort inhibiting pp2acα promotes the malignant phenotype of gastric cancer cells through the atm/mettl3 axis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410407/
https://www.ncbi.nlm.nih.gov/pubmed/34485508
http://dx.doi.org/10.1155/2021/1015293
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