Cargando…

Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis

This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit Cα (PP2Acα, encoded by PPP2CA) and methyltransferase-like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Zhaoxiang, Gao, Shan, Liang, Xiaojie, Lian, Chao, Chen, Jianquan, Fang, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410407/ https://www.ncbi.nlm.nih.gov/pubmed/34485508 http://dx.doi.org/10.1155/2021/1015293

Ejemplares similares

METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells
por: Lin, Sen, et al.
Publicado: (2019)

The molecular mechanism of METTL3 promoting the malignant progression of lung cancer
por: Ma, Chao, et al.
Publicado: (2022)

Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13
por: Parker, Haley V., et al.
Publicado: (2023)

Atypical ATMs: Broadening the phenotypic spectrum of ATM-associated hereditary cancer
por: Borja, Nicholas A., et al.
Publicado: (2023)

CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer
por: Zhang, Hui, et al.
Publicado: (2021)

The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer
por: Ge, Yiling, et al.
Publicado: (2023)

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

Novel targets for ATM-deficient malignancies
por: Winkler, Johannes, et al.
Publicado: (2014)

Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m(6)A/ATG5 axis
por: Wang, Ce, et al.
Publicado: (2023)

LncRNA-AC068228.1 Is a Novel Prognostic Biomarker That Promotes Malignant Phenotypes in Lung Adenocarcinoma
por: Jiang, Xiulin, et al.
Publicado: (2022)

RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis
por: Li, Yi, et al.
Publicado: (2022)

The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1‐positive acute lymphoblastic leukemia
por: Sun, Congcong, et al.
Publicado: (2019)

METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS
por: Chen, Jie-Xun, et al.
Publicado: (2023)

METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/β-Catenin Axis
por: Li, Changshu, et al.
Publicado: (2023)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

The Role of RNA Methyltransferase METTL3 in Normal and Malignant Hematopoiesis
por: Wu, Xia, et al.
Publicado: (2022)

m(6)A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
por: Liu, Pingyu, et al.
Publicado: (2021)

A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing
por: Qi, Shan, et al.
Publicado: (2023)

Analysis of METTL3 and METTL14 in hepatocellular carcinoma
por: Liu, Xiangxiang, et al.
Publicado: (2020)

N(6)-Methyladenosine Methyltransferase METTL3 Alleviates Diabetes-Induced Testicular Damage through Modulating TUG1/Clusterin Axis
por: Tian, Yuan, et al.
Publicado: (2023)

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα
por: Sinha, S, et al.
Publicado: (2013)

Atm reactivation reverses ataxia telangiectasia phenotypes in vivo
por: Di Siena, Sara, et al.
Publicado: (2018)

Evaluation of Caspase-9b and PP2Acα2 as potential biomarkers for chronic lymphocytic leukemia
por: Domínguez-Berrocal, Leticia, et al.
Publicado: (2016)

Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
por: Agabiti, Sherry S., et al.
Publicado: (2019)

Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury
por: Lu, Ke, et al.
Publicado: (2022)

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3β-PP2Ac-NF-κB Signaling Axis
por: Ren, Xiao-min, et al.
Publicado: (2016)

The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway
por: Xie, Yifan, et al.
Publicado: (2020)

PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites
por: Zhao, Mingxiu, et al.
Publicado: (2023)

Prevalence of deleterious ATM germline mutations in gastric cancer patients
por: Huang, Dong-Sheng, et al.
Publicado: (2015)

+HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Cao, Fengyu, et al.
Publicado: (2022)

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

Mutation at Intronic Repeats of the Ataxia-Telangiectasia Mutated (ATM) Gene and ATM Protein Loss in Primary Gastric Cancer with Microsatellite Instability
por: Kim, Hee Sung, et al.
Publicado: (2013)

METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway
por: Yang, Dong-Dong, et al.
Publicado: (2020)

Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers
por: Hara, Toshifumi, et al.
Publicado: (2022)

LncRNA AC098934 promotes proliferation and invasion in lung adenocarcinoma cells by combining METTL3 and m6A modifications
por: Huang, Shiqing, et al.
Publicado: (2022)

Oxford on Its Mettle
Publicado: (1891)

Epigenetic evidence of an Ac/Dc axis by VPA and SAHA
por: Lunke, Sebastian, et al.
Publicado: (2021)

Correction: Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

RNA binding to human METTL3-METTL14 restricts N(6)-deoxyadenosine methylation of DNA in vitro
por: Qi, Shan, et al.
Publicado: (2022)

RNAPII-dependent ATM signaling at collisions with replication forks
por: Einig, Elias, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rs00rgokcjc5gka3t9enktr5ti