Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon

Angiotensin-converting enzyme 2 (ACE2) has been identified as the key receptor of SARS coronavirus that plays a key role in the pathogenesis of SARS. It is known that ACE2 mRNA can be expressed in most organs. However, the protein expression of ACE2 is not clear yet. To explore the role of ACE2 as a...

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Autores principales: Liu, Yiwen, Wu, Qing, Wan, Dongmei, He, Huiqin, Lin, Hailian, Wang, Kelang, Que, Genxiang, Wang, Yuanyuan, Chen, Yongjun, Tang, Xiaoqing, Wu, Lingbo, Yang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410421/
https://www.ncbi.nlm.nih.gov/pubmed/34484401
http://dx.doi.org/10.1155/2021/6949902
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author Liu, Yiwen
Wu, Qing
Wan, Dongmei
He, Huiqin
Lin, Hailian
Wang, Kelang
Que, Genxiang
Wang, Yuanyuan
Chen, Yongjun
Tang, Xiaoqing
Wu, Lingbo
Yang, Xuefeng
author_facet Liu, Yiwen
Wu, Qing
Wan, Dongmei
He, Huiqin
Lin, Hailian
Wang, Kelang
Que, Genxiang
Wang, Yuanyuan
Chen, Yongjun
Tang, Xiaoqing
Wu, Lingbo
Yang, Xuefeng
author_sort Liu, Yiwen
collection PubMed
description Angiotensin-converting enzyme 2 (ACE2) has been identified as the key receptor of SARS coronavirus that plays a key role in the pathogenesis of SARS. It is known that ACE2 mRNA can be expressed in most organs. However, the protein expression of ACE2 is not clear yet. To explore the role of ACE2 as a precipitating factor in digestive organ damage in COVID-19, this study investigated the expression of ACE2 protein in the human liver, esophagus, stomach, and colon. The result showed that ACE2 can be expressed in the liver, esophagus, stomach, and colon, which suggests SARS-CoV-2 may enter the digestive system through ACE2 and cause liver damage and gastrointestinal damage. It is hoped that the result of the study will provide a new strategy for the prevention and treatment of digestive organ damage under COVID-19.
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spelling pubmed-84104212021-09-02 Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon Liu, Yiwen Wu, Qing Wan, Dongmei He, Huiqin Lin, Hailian Wang, Kelang Que, Genxiang Wang, Yuanyuan Chen, Yongjun Tang, Xiaoqing Wu, Lingbo Yang, Xuefeng Evid Based Complement Alternat Med Research Article Angiotensin-converting enzyme 2 (ACE2) has been identified as the key receptor of SARS coronavirus that plays a key role in the pathogenesis of SARS. It is known that ACE2 mRNA can be expressed in most organs. However, the protein expression of ACE2 is not clear yet. To explore the role of ACE2 as a precipitating factor in digestive organ damage in COVID-19, this study investigated the expression of ACE2 protein in the human liver, esophagus, stomach, and colon. The result showed that ACE2 can be expressed in the liver, esophagus, stomach, and colon, which suggests SARS-CoV-2 may enter the digestive system through ACE2 and cause liver damage and gastrointestinal damage. It is hoped that the result of the study will provide a new strategy for the prevention and treatment of digestive organ damage under COVID-19. Hindawi 2021-08-25 /pmc/articles/PMC8410421/ /pubmed/34484401 http://dx.doi.org/10.1155/2021/6949902 Text en Copyright © 2021 Yiwen Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yiwen
Wu, Qing
Wan, Dongmei
He, Huiqin
Lin, Hailian
Wang, Kelang
Que, Genxiang
Wang, Yuanyuan
Chen, Yongjun
Tang, Xiaoqing
Wu, Lingbo
Yang, Xuefeng
Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon
title Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon
title_full Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon
title_fullStr Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon
title_full_unstemmed Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon
title_short Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon
title_sort expression and possible significance of ace2 in the human liver, esophagus, stomach, and colon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410421/
https://www.ncbi.nlm.nih.gov/pubmed/34484401
http://dx.doi.org/10.1155/2021/6949902
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