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Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation

The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at chi...

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Autores principales: Xia, Zhichao, Wang, Cheng, Hancock, Roeland, Vandermosten, Maaike, Hoeft, Fumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410543/
https://www.ncbi.nlm.nih.gov/pubmed/34219304
http://dx.doi.org/10.1002/hbm.25567
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author Xia, Zhichao
Wang, Cheng
Hancock, Roeland
Vandermosten, Maaike
Hoeft, Fumiko
author_facet Xia, Zhichao
Wang, Cheng
Hancock, Roeland
Vandermosten, Maaike
Hoeft, Fumiko
author_sort Xia, Zhichao
collection PubMed
description The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at childbirth (PatAGE) is known as the most prominent risk factor for de novo mutation, which has been repeatedly shown by molecular genetic studies. As one of the first efforts, we performed a preliminary investigation of the relationship between PatAGE, offspring's reading, and brain structure in a longitudinal neuroimaging study following 51 children from kindergarten through third grade. The results showed that greater PatAGE was significantly associated with worse reading, explaining an additional 9.5% of the variance after controlling for a number of confounds—including familial factors and cognitive‐linguistic reading precursors. Moreover, this effect was mediated by volumetric maturation of the left posterior thalamus from ages 5 to 8. Complementary analyses indicated the PatAGE‐related thalamic region was most likely located in the pulvinar nuclei and related to the dorsal attention network by using brain atlases, public datasets, and offspring's diffusion imaging data. Altogether, these findings provide novel insights into neurocognitive mechanisms underlying the PatAGE effect on reading acquisition during its earliest phase and suggest promising areas of future research.
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spelling pubmed-84105432021-09-03 Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation Xia, Zhichao Wang, Cheng Hancock, Roeland Vandermosten, Maaike Hoeft, Fumiko Hum Brain Mapp Research Articles The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at childbirth (PatAGE) is known as the most prominent risk factor for de novo mutation, which has been repeatedly shown by molecular genetic studies. As one of the first efforts, we performed a preliminary investigation of the relationship between PatAGE, offspring's reading, and brain structure in a longitudinal neuroimaging study following 51 children from kindergarten through third grade. The results showed that greater PatAGE was significantly associated with worse reading, explaining an additional 9.5% of the variance after controlling for a number of confounds—including familial factors and cognitive‐linguistic reading precursors. Moreover, this effect was mediated by volumetric maturation of the left posterior thalamus from ages 5 to 8. Complementary analyses indicated the PatAGE‐related thalamic region was most likely located in the pulvinar nuclei and related to the dorsal attention network by using brain atlases, public datasets, and offspring's diffusion imaging data. Altogether, these findings provide novel insights into neurocognitive mechanisms underlying the PatAGE effect on reading acquisition during its earliest phase and suggest promising areas of future research. John Wiley & Sons, Inc. 2021-07-04 /pmc/articles/PMC8410543/ /pubmed/34219304 http://dx.doi.org/10.1002/hbm.25567 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Xia, Zhichao
Wang, Cheng
Hancock, Roeland
Vandermosten, Maaike
Hoeft, Fumiko
Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
title Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
title_full Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
title_fullStr Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
title_full_unstemmed Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
title_short Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
title_sort development of thalamus mediates paternal age effect on offspring reading: a preliminary investigation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410543/
https://www.ncbi.nlm.nih.gov/pubmed/34219304
http://dx.doi.org/10.1002/hbm.25567
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