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Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation
The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at chi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410543/ https://www.ncbi.nlm.nih.gov/pubmed/34219304 http://dx.doi.org/10.1002/hbm.25567 |
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author | Xia, Zhichao Wang, Cheng Hancock, Roeland Vandermosten, Maaike Hoeft, Fumiko |
author_facet | Xia, Zhichao Wang, Cheng Hancock, Roeland Vandermosten, Maaike Hoeft, Fumiko |
author_sort | Xia, Zhichao |
collection | PubMed |
description | The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at childbirth (PatAGE) is known as the most prominent risk factor for de novo mutation, which has been repeatedly shown by molecular genetic studies. As one of the first efforts, we performed a preliminary investigation of the relationship between PatAGE, offspring's reading, and brain structure in a longitudinal neuroimaging study following 51 children from kindergarten through third grade. The results showed that greater PatAGE was significantly associated with worse reading, explaining an additional 9.5% of the variance after controlling for a number of confounds—including familial factors and cognitive‐linguistic reading precursors. Moreover, this effect was mediated by volumetric maturation of the left posterior thalamus from ages 5 to 8. Complementary analyses indicated the PatAGE‐related thalamic region was most likely located in the pulvinar nuclei and related to the dorsal attention network by using brain atlases, public datasets, and offspring's diffusion imaging data. Altogether, these findings provide novel insights into neurocognitive mechanisms underlying the PatAGE effect on reading acquisition during its earliest phase and suggest promising areas of future research. |
format | Online Article Text |
id | pubmed-8410543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84105432021-09-03 Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation Xia, Zhichao Wang, Cheng Hancock, Roeland Vandermosten, Maaike Hoeft, Fumiko Hum Brain Mapp Research Articles The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at childbirth (PatAGE) is known as the most prominent risk factor for de novo mutation, which has been repeatedly shown by molecular genetic studies. As one of the first efforts, we performed a preliminary investigation of the relationship between PatAGE, offspring's reading, and brain structure in a longitudinal neuroimaging study following 51 children from kindergarten through third grade. The results showed that greater PatAGE was significantly associated with worse reading, explaining an additional 9.5% of the variance after controlling for a number of confounds—including familial factors and cognitive‐linguistic reading precursors. Moreover, this effect was mediated by volumetric maturation of the left posterior thalamus from ages 5 to 8. Complementary analyses indicated the PatAGE‐related thalamic region was most likely located in the pulvinar nuclei and related to the dorsal attention network by using brain atlases, public datasets, and offspring's diffusion imaging data. Altogether, these findings provide novel insights into neurocognitive mechanisms underlying the PatAGE effect on reading acquisition during its earliest phase and suggest promising areas of future research. John Wiley & Sons, Inc. 2021-07-04 /pmc/articles/PMC8410543/ /pubmed/34219304 http://dx.doi.org/10.1002/hbm.25567 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Xia, Zhichao Wang, Cheng Hancock, Roeland Vandermosten, Maaike Hoeft, Fumiko Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation |
title | Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation |
title_full | Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation |
title_fullStr | Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation |
title_full_unstemmed | Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation |
title_short | Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation |
title_sort | development of thalamus mediates paternal age effect on offspring reading: a preliminary investigation |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410543/ https://www.ncbi.nlm.nih.gov/pubmed/34219304 http://dx.doi.org/10.1002/hbm.25567 |
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