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Dynamic functional connectivity profile of the salience network across the life span

The insular cortex and anterior cingulate cortex together comprise the salience or midcingulo‐insular network, involved in detecting salient events and initiating control signals to mediate brain network dynamics. The extent to which functional coupling between the salience network and the rest of t...

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Autores principales: Snyder, William, Uddin, Lucina Q., Nomi, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410581/
https://www.ncbi.nlm.nih.gov/pubmed/34312945
http://dx.doi.org/10.1002/hbm.25581
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author Snyder, William
Uddin, Lucina Q.
Nomi, Jason S.
author_facet Snyder, William
Uddin, Lucina Q.
Nomi, Jason S.
author_sort Snyder, William
collection PubMed
description The insular cortex and anterior cingulate cortex together comprise the salience or midcingulo‐insular network, involved in detecting salient events and initiating control signals to mediate brain network dynamics. The extent to which functional coupling between the salience network and the rest of the brain undergoes changes due to development and aging is at present largely unexplored. Here, we examine dynamic functional connectivity (dFC) of the salience network in a large life span sample (n = 601; 6–85 years old). A sliding‐window analysis and k‐means clustering revealed five states of dFC formed with the salience network, characterized by either widespread asynchrony or different patterns of synchrony between the salience network and other brain regions. We determined the frequency, dwell time, total transitions, and specific state‐to‐state transitions for each state and subject, regressing the metrics with subjects' age to identify life span trends. A dynamic state characterized by low connectivity between the salience network and the rest of the brain had a strong positive quadratic relationship between age and both frequency and dwell time. Additional frequency, dwell time, total transitions, and state‐to‐state transition trends were observed with other salience network states. Our results highlight the metastable dynamics of the salience network and its role in the maturation of brain regions critical for cognition.
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spelling pubmed-84105812021-09-03 Dynamic functional connectivity profile of the salience network across the life span Snyder, William Uddin, Lucina Q. Nomi, Jason S. Hum Brain Mapp Research Articles The insular cortex and anterior cingulate cortex together comprise the salience or midcingulo‐insular network, involved in detecting salient events and initiating control signals to mediate brain network dynamics. The extent to which functional coupling between the salience network and the rest of the brain undergoes changes due to development and aging is at present largely unexplored. Here, we examine dynamic functional connectivity (dFC) of the salience network in a large life span sample (n = 601; 6–85 years old). A sliding‐window analysis and k‐means clustering revealed five states of dFC formed with the salience network, characterized by either widespread asynchrony or different patterns of synchrony between the salience network and other brain regions. We determined the frequency, dwell time, total transitions, and specific state‐to‐state transitions for each state and subject, regressing the metrics with subjects' age to identify life span trends. A dynamic state characterized by low connectivity between the salience network and the rest of the brain had a strong positive quadratic relationship between age and both frequency and dwell time. Additional frequency, dwell time, total transitions, and state‐to‐state transition trends were observed with other salience network states. Our results highlight the metastable dynamics of the salience network and its role in the maturation of brain regions critical for cognition. John Wiley & Sons, Inc. 2021-07-26 /pmc/articles/PMC8410581/ /pubmed/34312945 http://dx.doi.org/10.1002/hbm.25581 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Snyder, William
Uddin, Lucina Q.
Nomi, Jason S.
Dynamic functional connectivity profile of the salience network across the life span
title Dynamic functional connectivity profile of the salience network across the life span
title_full Dynamic functional connectivity profile of the salience network across the life span
title_fullStr Dynamic functional connectivity profile of the salience network across the life span
title_full_unstemmed Dynamic functional connectivity profile of the salience network across the life span
title_short Dynamic functional connectivity profile of the salience network across the life span
title_sort dynamic functional connectivity profile of the salience network across the life span
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410581/
https://www.ncbi.nlm.nih.gov/pubmed/34312945
http://dx.doi.org/10.1002/hbm.25581
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