Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

We utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of Autism Spectrum Disorder (ASD) with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development. Patients with this mutation present with...

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Detalles Bibliográficos
Autores principales: de Jong, Job O., Llapashtica, Ceyda, Genestine, Matthieu, Strauss, Kevin, Provenzano, Frank, Sun, Yan, Zhu, Huixiang, Cortese, Giuseppe P., Brundu, Francesco, Brigatti, Karlla W., Corneo, Barbara, Migliori, Bianca, Tomer, Raju, Kushner, Steven A., Kellendonk, Christoph, Javitch, Jonathan A., Xu, Bin, Markx, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410758/
https://www.ncbi.nlm.nih.gov/pubmed/34471112
http://dx.doi.org/10.1038/s41467-021-24358-4

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