Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Post-transcriptional gene regulation in T cells is dynamic and complex as targeted transcripts respond to various factors. This is evident for the Icos mRNA encoding an essential costimulatory receptor that is regulated by several RNA-binding proteins (RBP), including Roquin-1 and Roquin-2. Here, we...

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Detalles Bibliográficos
Autores principales: Hoefig, Kai P., Reim, Alexander, Gallus, Christian, Wong, Elaine H., Behrens, Gesine, Conrad, Christine, Xu, Meng, Kifinger, Lisa, Ito-Kureha, Taku, Defourny, Kyra A. Y., Geerlof, Arie, Mautner, Josef, Hauck, Stefanie M., Baumjohann, Dirk, Feederle, Regina, Mann, Matthias, Wierer, Michael, Glasmacher, Elke, Heissmeyer, Vigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410761/
https://www.ncbi.nlm.nih.gov/pubmed/34471108
http://dx.doi.org/10.1038/s41467-021-25345-5

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