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Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients
Dopaminergic function is a critical transdiagnostic neurophysiological dimension with broad relevance in psychiatry. Normalized T2*-weighted (nT2*w) imaging has been previously investigated as a method to quantify biological properties of tissue in the striatum (e.g., tissue iron), providing a widel...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410762/ https://www.ncbi.nlm.nih.gov/pubmed/34471098 http://dx.doi.org/10.1038/s41398-021-01553-x |
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author | Price, Rebecca B. Tervo-Clemmens, Brenden C. Panny, Benjamin Degutis, Michelle Griffo, Angela Woody, Mary |
author_facet | Price, Rebecca B. Tervo-Clemmens, Brenden C. Panny, Benjamin Degutis, Michelle Griffo, Angela Woody, Mary |
author_sort | Price, Rebecca B. |
collection | PubMed |
description | Dopaminergic function is a critical transdiagnostic neurophysiological dimension with broad relevance in psychiatry. Normalized T2*-weighted (nT2*w) imaging has been previously investigated as a method to quantify biological properties of tissue in the striatum (e.g., tissue iron), providing a widely available, in vivo marker with potential relevance to dopaminergic function; but no prior study to our knowledge has examined this neuroimaging marker in clinical depression. In a treatment-seeking, clinically depressed sample (n = 110), we quantified tissue iron (nT2*w) in striatal regions. We assessed test-retest reliability and correlated values with dimensional features across levels of analysis, including demographic/biological (sex, age, Body Mass Index), neuroanatomical (hippocampal atrophy, which was quantified using a recently validated machine-learning algorithm), and performance-based (Affective Go/NoGo task performance) indices with relevance to depressive neurocognition. Across patients, decreased tissue iron concentration (as indexed by higher nT2*w) in striatal regions correlated with indices of decreased cognitive-affective function on the Affective Go/NoGo task. Greater caudate nT2*w also correlated with greater hippocampal atrophy. Striatal tissue iron concentrations were robustly lower in female patients than males but gender differences did not explain relations with other neurocognitive variables. A widely available fMRI index of striatal tissue properties, which exhibited strong psychometric properties and can be readily quantified from most fMRI datasets irrespective of study-specific features such as task design, showed relevance to multiple biobehavioral markers of pathophysiology in the context of moderate-to-severe, treatment-resistant depression. Striatal tissue iron may play a role in dimensional and subgroup-specific features of depression, with implications for future research on depression heterogeneity. |
format | Online Article Text |
id | pubmed-8410762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84107622021-09-22 Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients Price, Rebecca B. Tervo-Clemmens, Brenden C. Panny, Benjamin Degutis, Michelle Griffo, Angela Woody, Mary Transl Psychiatry Article Dopaminergic function is a critical transdiagnostic neurophysiological dimension with broad relevance in psychiatry. Normalized T2*-weighted (nT2*w) imaging has been previously investigated as a method to quantify biological properties of tissue in the striatum (e.g., tissue iron), providing a widely available, in vivo marker with potential relevance to dopaminergic function; but no prior study to our knowledge has examined this neuroimaging marker in clinical depression. In a treatment-seeking, clinically depressed sample (n = 110), we quantified tissue iron (nT2*w) in striatal regions. We assessed test-retest reliability and correlated values with dimensional features across levels of analysis, including demographic/biological (sex, age, Body Mass Index), neuroanatomical (hippocampal atrophy, which was quantified using a recently validated machine-learning algorithm), and performance-based (Affective Go/NoGo task performance) indices with relevance to depressive neurocognition. Across patients, decreased tissue iron concentration (as indexed by higher nT2*w) in striatal regions correlated with indices of decreased cognitive-affective function on the Affective Go/NoGo task. Greater caudate nT2*w also correlated with greater hippocampal atrophy. Striatal tissue iron concentrations were robustly lower in female patients than males but gender differences did not explain relations with other neurocognitive variables. A widely available fMRI index of striatal tissue properties, which exhibited strong psychometric properties and can be readily quantified from most fMRI datasets irrespective of study-specific features such as task design, showed relevance to multiple biobehavioral markers of pathophysiology in the context of moderate-to-severe, treatment-resistant depression. Striatal tissue iron may play a role in dimensional and subgroup-specific features of depression, with implications for future research on depression heterogeneity. Nature Publishing Group UK 2021-09-01 /pmc/articles/PMC8410762/ /pubmed/34471098 http://dx.doi.org/10.1038/s41398-021-01553-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Price, Rebecca B. Tervo-Clemmens, Brenden C. Panny, Benjamin Degutis, Michelle Griffo, Angela Woody, Mary Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients |
title | Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients |
title_full | Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients |
title_fullStr | Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients |
title_full_unstemmed | Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients |
title_short | Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients |
title_sort | biobehavioral correlates of an fmri index of striatal tissue iron in depressed patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410762/ https://www.ncbi.nlm.nih.gov/pubmed/34471098 http://dx.doi.org/10.1038/s41398-021-01553-x |
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