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Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 201...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410810/ https://www.ncbi.nlm.nih.gov/pubmed/34471193 http://dx.doi.org/10.1038/s41598-021-97154-1 |
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author | Nam, Ki-Woong Kwon, Hyung-Min Lee, Yong-Seok Kim, Jeong-Min Ko, Sang-Bae |
author_facet | Nam, Ki-Woong Kwon, Hyung-Min Lee, Yong-Seok Kim, Jeong-Min Ko, Sang-Bae |
author_sort | Nam, Ki-Woong |
collection | PubMed |
description | Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 2010 to 2016. Early neurological deterioration (END) was defined as a ≥ 2-point increase in the total NIHSS score or a ≥ 1-point increase in the motor NIHSS score within the first 72 h. We defined an unfavorable outcome as the modified Rankin Scale (mRS) score ≥ 3 points. We analyzed cSVD separately for each subtype including white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleed (CMB). A total of 179 cryptogenic stroke patients with active cancer were evaluated. In the multivariable analysis, SBI was significantly associated with END (adjusted odds ratio = 3.97, 95% confidence interval: 1.53–10.33). This close relationship between SBI and END increased proportionally with an increase in SBI burden. However, WMH and CMB showed no significant association with END. None of the cSVD subtypes showed a statistically significant relationship with the 3-month unfavorable outcome. SBI was the only parameter closely associated with END in cryptogenic stroke patients with active cancer. |
format | Online Article Text |
id | pubmed-8410810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84108102021-09-03 Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer Nam, Ki-Woong Kwon, Hyung-Min Lee, Yong-Seok Kim, Jeong-Min Ko, Sang-Bae Sci Rep Article Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 2010 to 2016. Early neurological deterioration (END) was defined as a ≥ 2-point increase in the total NIHSS score or a ≥ 1-point increase in the motor NIHSS score within the first 72 h. We defined an unfavorable outcome as the modified Rankin Scale (mRS) score ≥ 3 points. We analyzed cSVD separately for each subtype including white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleed (CMB). A total of 179 cryptogenic stroke patients with active cancer were evaluated. In the multivariable analysis, SBI was significantly associated with END (adjusted odds ratio = 3.97, 95% confidence interval: 1.53–10.33). This close relationship between SBI and END increased proportionally with an increase in SBI burden. However, WMH and CMB showed no significant association with END. None of the cSVD subtypes showed a statistically significant relationship with the 3-month unfavorable outcome. SBI was the only parameter closely associated with END in cryptogenic stroke patients with active cancer. Nature Publishing Group UK 2021-09-01 /pmc/articles/PMC8410810/ /pubmed/34471193 http://dx.doi.org/10.1038/s41598-021-97154-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nam, Ki-Woong Kwon, Hyung-Min Lee, Yong-Seok Kim, Jeong-Min Ko, Sang-Bae Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title | Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_full | Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_fullStr | Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_full_unstemmed | Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_short | Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_sort | effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410810/ https://www.ncbi.nlm.nih.gov/pubmed/34471193 http://dx.doi.org/10.1038/s41598-021-97154-1 |
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