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Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “additive cytotoxicity” by which time-dependent in...

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Detalles Bibliográficos
Autores principales:	Weigelin, Bettina, den Boer, Annemieke Th., Wagena, Esther, Broen, Kelly, Dolstra, Harry, de Boer, Rob J., Figdor, Carl G., Textor, Johannes, Friedl, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410835/ https://www.ncbi.nlm.nih.gov/pubmed/34471116 http://dx.doi.org/10.1038/s41467-021-25282-3

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