Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity

Cyclic adenosine monophosphate (cAMP) is a master regulator of mitochondrial metabolism but its precise mechanism of action yet remains unclear. Here, we found that a dietary saturated fatty acid (FA), palmitate increased intracellular cAMP synthesis through the palmitoylation of soluble adenylyl cy...

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Detalles Bibliográficos
Autores principales: Laudette, Marion, Sainte-Marie, Yannis, Cousin, Grégoire, Bergonnier, Dorian, Belhabib, Ismahane, Brun, Stéphanie, Formoso, Karina, Laib, Loubna, Tortosa, Florence, Bergoglio, Camille, Marcheix, Bertrand, Borén, Jan, Lairez, Olivier, Fauconnier, Jérémy, Lucas, Alexandre, Mialet-Perez, Jeanne, Moro, Cédric, Lezoualc’h, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410846/
https://www.ncbi.nlm.nih.gov/pubmed/34471096
http://dx.doi.org/10.1038/s41419-021-04113-9

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