Structure of the human marker of self 5-transmembrane receptor CD47

CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface marker of self that binds SIRPα and inhibits macrophage phagocytosis, and cancer immuno-therapy approaches in clinical trials are focused on blocking CD47/SIRPα interactio...

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Detalles Bibliográficos
Autores principales: Fenalti, Gustavo, Villanueva, Nicolas, Griffith, Mark, Pagarigan, Barbra, Lakkaraju, Sirish Kaushik, Huang, Richard Y.-C., Ladygina, Nadia, Sharma, Alok, Mikolon, David, Abbasian, Mahan, Johnson, Jeffrey, Hadjivassiliou, Haralambos, Zhu, Dan, Chamberlain, Philip P., Cho, Ho, Hariharan, Kandasamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410850/
https://www.ncbi.nlm.nih.gov/pubmed/34471125
http://dx.doi.org/10.1038/s41467-021-25475-w

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