[(18)F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases

While [(18)F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of ‘off-target’ [(18)F]-AV-1451 binding to neuromelanin in the substantia nigra could be a surrogate marker of Lewy body diseases. [(18)F]-AV-1451 binding was measu...

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Detalles Bibliográficos
Autores principales: Mak, Elijah, Kouli, Antonina, Holland, Negin, Nicastro, Nicolas, Savulich, George, Surendranathan, Ajenthan, Malpetti, Maura, Manavaki, Roido, Hong, Young T, Fryer, Tim D, Aigbirhio, Franklin, Rowe, James B, O’Brien, John T, Williams-Gray, Caroline H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410984/
https://www.ncbi.nlm.nih.gov/pubmed/34485906
http://dx.doi.org/10.1093/braincomms/fcab177

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