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Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer

Triple-negative breast cancer (TNBC), which is the most malignant subtype of breast cancer (BC), accounts for 10%–20% of all BC cases. TNBC, which occurs more frequently in young women, is characterized by high rates of cell proliferation and metastasis and poor prognosis. Chemotherapy is the primar...

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Autores principales: Tian, Tian, Zhao, Yangzhi, Zheng, Jingying, Jin, Shunzi, Liu, Zhongshan, Wang, Tiejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411013/
https://www.ncbi.nlm.nih.gov/pubmed/34513294
http://dx.doi.org/10.1016/j.omtn.2021.06.017
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author Tian, Tian
Zhao, Yangzhi
Zheng, Jingying
Jin, Shunzi
Liu, Zhongshan
Wang, Tiejun
author_facet Tian, Tian
Zhao, Yangzhi
Zheng, Jingying
Jin, Shunzi
Liu, Zhongshan
Wang, Tiejun
author_sort Tian, Tian
collection PubMed
description Triple-negative breast cancer (TNBC), which is the most malignant subtype of breast cancer (BC), accounts for 10%–20% of all BC cases. TNBC, which occurs more frequently in young women, is characterized by high rates of cell proliferation and metastasis and poor prognosis. Chemotherapy is the primary systemic therapeutic strategy for TNBC. However, chemotherapy is largely unsuccessful, and effective targeted therapies for TNBC have not been established. Therefore, it is a matter of great urgency to identify precise molecular targets for the promising prognosis of patients with TNBC. Circular RNAs (circRNAs), which are a type of non-coding RNAs (ncRNAs), are abundantly expressed in the eukaryotic cells and exhibit diverse cellular functions. The roles of circRNAs are to sponge microRNA or RNA-binding proteins, regulate gene expression, and serve as templates for translation. Here, we review the current findings on the potential of circRNAs as a diagnostic, prognostic, and therapeutic biomarker for TNBC. However, further studies are essential to elucidate the functions of circRNAs in TNBC. This review also discusses the current limitations and future directions of TNBC-associated circRNAs, which can facilitate the translation of experimental research into clinical application.
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spelling pubmed-84110132021-09-10 Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer Tian, Tian Zhao, Yangzhi Zheng, Jingying Jin, Shunzi Liu, Zhongshan Wang, Tiejun Mol Ther Nucleic Acids Review Triple-negative breast cancer (TNBC), which is the most malignant subtype of breast cancer (BC), accounts for 10%–20% of all BC cases. TNBC, which occurs more frequently in young women, is characterized by high rates of cell proliferation and metastasis and poor prognosis. Chemotherapy is the primary systemic therapeutic strategy for TNBC. However, chemotherapy is largely unsuccessful, and effective targeted therapies for TNBC have not been established. Therefore, it is a matter of great urgency to identify precise molecular targets for the promising prognosis of patients with TNBC. Circular RNAs (circRNAs), which are a type of non-coding RNAs (ncRNAs), are abundantly expressed in the eukaryotic cells and exhibit diverse cellular functions. The roles of circRNAs are to sponge microRNA or RNA-binding proteins, regulate gene expression, and serve as templates for translation. Here, we review the current findings on the potential of circRNAs as a diagnostic, prognostic, and therapeutic biomarker for TNBC. However, further studies are essential to elucidate the functions of circRNAs in TNBC. This review also discusses the current limitations and future directions of TNBC-associated circRNAs, which can facilitate the translation of experimental research into clinical application. American Society of Gene & Cell Therapy 2021-07-02 /pmc/articles/PMC8411013/ /pubmed/34513294 http://dx.doi.org/10.1016/j.omtn.2021.06.017 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tian, Tian
Zhao, Yangzhi
Zheng, Jingying
Jin, Shunzi
Liu, Zhongshan
Wang, Tiejun
Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
title Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
title_full Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
title_fullStr Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
title_full_unstemmed Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
title_short Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
title_sort circular rna: a potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411013/
https://www.ncbi.nlm.nih.gov/pubmed/34513294
http://dx.doi.org/10.1016/j.omtn.2021.06.017
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