Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS

Sclerostin (SOST), a regulator of bone formation in osteocytes, inhibits the canonical Wnt signaling by interacting with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to prevent Wnt binding. Loss-of-function mutations of the SOST gene caused massive bone outgrowth and SOST-null mouse...

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Detalles Bibliográficos
Autores principales: Jeong, Yejing, Kim, Jinuk, Choi, Hee-Jung, Chung, Ka Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411024/
https://www.ncbi.nlm.nih.gov/pubmed/33833136
http://dx.doi.org/10.4062/biomolther.2020.234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411024/
https://www.ncbi.nlm.nih.gov/pubmed/33833136
http://dx.doi.org/10.4062/biomolther.2020.234

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