The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer

BACKGROUND: This study aimed to investigate the correlation between miRNA-216b expression in patients with non-small cell lung cancer (NSCLC) and (18)F-fluorodeoxyglucose (FDG) uptake by PET/CT and to explore the clinical application value of 18F-FDG PET/CT in miRNA-216b based on therapy for NSCLC....

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Autores principales: Zuo, Mingfei, Yao, Lan, Wen, Lijuan, Shen, Jianfei, Zhang, Na, Bai, Tian, Huang, Qicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411519/
https://www.ncbi.nlm.nih.gov/pubmed/34470640
http://dx.doi.org/10.1186/s12957-021-02376-2
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author Zuo, Mingfei
Yao, Lan
Wen, Lijuan
Shen, Jianfei
Zhang, Na
Bai, Tian
Huang, Qicheng
author_facet Zuo, Mingfei
Yao, Lan
Wen, Lijuan
Shen, Jianfei
Zhang, Na
Bai, Tian
Huang, Qicheng
author_sort Zuo, Mingfei
collection PubMed
description BACKGROUND: This study aimed to investigate the correlation between miRNA-216b expression in patients with non-small cell lung cancer (NSCLC) and (18)F-fluorodeoxyglucose (FDG) uptake by PET/CT and to explore the clinical application value of 18F-FDG PET/CT in miRNA-216b based on therapy for NSCLC. METHODS: Eighty patients with NSCLC and 40 healthy subjects were enrolled in our study. The SUVmax of the lesion area by PET/CT imaging was calculated. SUVmax represented the highest concentration of 18F-FDG in the lesion. The expression of miRNA-216b in the plasma and fiber bronchoscopic puncture of NSCLC patients was detected by RT qPCR. Then Pearson correlation analysis was used to analyze the correlation between miRNA-216b expression and 18F-FDG uptake in patients with different types of NSCLC. RESULTS: Compared with healthy subjects, SUVmax of early adenocarcinoma and advanced adenocarcinoma were increased. Compared with healthy subjects, SUVmax of early squamous and advanced squamous were increased. And the SUVmax content of advanced adenocarcinoma and squamous cell carcinoma was higher than that of early adenocarcinoma and squamous cell carcinoma. Compared with healthy subjects, the expression of miRNA-216b in the plasma of patients with early and advanced adenocarcinoma was reduced, and the expression of miRNA-216b in the plasma of patients with early and advanced squamous cell carcinoma was reduced. Compared with adjacent tissues, the expression of miRNA-216b in early adenocarcinoma tissues and advanced adenocarcinoma tissues was reduced, and the expression in early squamous cell carcinoma and advanced squamous cell carcinoma was reduced. Pearson correlation analysis showed a negative correlation between SUVmax and miRNA-216b (plasma and tissue) in patients with four types of NSCLC. CONCLUSION: miRNA-216b expression was negatively correlated with (18)F-FDG uptake in NSCLC. miRNA-216b could be used for the classification and staging of non-small cell lung cancer. (18)F-FDG PET/CT may be used to evaluate the therapeutic response in application of miRNA-216b-based cancer treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-021-02376-2.
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spelling pubmed-84115192021-09-09 The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer Zuo, Mingfei Yao, Lan Wen, Lijuan Shen, Jianfei Zhang, Na Bai, Tian Huang, Qicheng World J Surg Oncol Research BACKGROUND: This study aimed to investigate the correlation between miRNA-216b expression in patients with non-small cell lung cancer (NSCLC) and (18)F-fluorodeoxyglucose (FDG) uptake by PET/CT and to explore the clinical application value of 18F-FDG PET/CT in miRNA-216b based on therapy for NSCLC. METHODS: Eighty patients with NSCLC and 40 healthy subjects were enrolled in our study. The SUVmax of the lesion area by PET/CT imaging was calculated. SUVmax represented the highest concentration of 18F-FDG in the lesion. The expression of miRNA-216b in the plasma and fiber bronchoscopic puncture of NSCLC patients was detected by RT qPCR. Then Pearson correlation analysis was used to analyze the correlation between miRNA-216b expression and 18F-FDG uptake in patients with different types of NSCLC. RESULTS: Compared with healthy subjects, SUVmax of early adenocarcinoma and advanced adenocarcinoma were increased. Compared with healthy subjects, SUVmax of early squamous and advanced squamous were increased. And the SUVmax content of advanced adenocarcinoma and squamous cell carcinoma was higher than that of early adenocarcinoma and squamous cell carcinoma. Compared with healthy subjects, the expression of miRNA-216b in the plasma of patients with early and advanced adenocarcinoma was reduced, and the expression of miRNA-216b in the plasma of patients with early and advanced squamous cell carcinoma was reduced. Compared with adjacent tissues, the expression of miRNA-216b in early adenocarcinoma tissues and advanced adenocarcinoma tissues was reduced, and the expression in early squamous cell carcinoma and advanced squamous cell carcinoma was reduced. Pearson correlation analysis showed a negative correlation between SUVmax and miRNA-216b (plasma and tissue) in patients with four types of NSCLC. CONCLUSION: miRNA-216b expression was negatively correlated with (18)F-FDG uptake in NSCLC. miRNA-216b could be used for the classification and staging of non-small cell lung cancer. (18)F-FDG PET/CT may be used to evaluate the therapeutic response in application of miRNA-216b-based cancer treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-021-02376-2. BioMed Central 2021-09-01 /pmc/articles/PMC8411519/ /pubmed/34470640 http://dx.doi.org/10.1186/s12957-021-02376-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zuo, Mingfei
Yao, Lan
Wen, Lijuan
Shen, Jianfei
Zhang, Na
Bai, Tian
Huang, Qicheng
The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer
title The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer
title_full The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer
title_fullStr The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer
title_full_unstemmed The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer
title_short The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer
title_sort expression of mirna-216b is negatively correlated with 18f-fdg uptake in non-small cell lung cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411519/
https://www.ncbi.nlm.nih.gov/pubmed/34470640
http://dx.doi.org/10.1186/s12957-021-02376-2
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