The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin

BACKGROUND: Glioblastoma multiforme (GBM), a lethal brain tumor, remains the most daunting challenge in cancer therapy. Overexpression and constitutive activation of PDGFs and PDGFRα are observed in most GBM; however, available inhibitors targeting isolated signaling pathways are minimally effective...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Gong, Wang, Yin, Ge, Pengfei, Bailey, Christopher, Zhang, Peng, Zhang, Di, Meng, Zhaoli, Qi, Chong, Chen, Qian, Chen, Jingtao, Niu, Junqi, Zheng, Pan, Liu, Yang, Liu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411541/
https://www.ncbi.nlm.nih.gov/pubmed/34470658
http://dx.doi.org/10.1186/s13046-021-02082-7

Ejemplares similares

Ejemplares similares