Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice

Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice with elevated levels of KYNA, induced by targeted deletion of kynurenine 3-monooxygenase (KMO), as...

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Detalles Bibliográficos
Autores principales: Imbeault, Sophie, Gubert Olivé, Max, Jungholm, Oscar, Erhardt, Sophie, Wigström, Holger, Engberg, Göran, Jardemark, Kent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411644/
https://www.ncbi.nlm.nih.gov/pubmed/34483669
http://dx.doi.org/10.1177/11786469211041368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411644/
https://www.ncbi.nlm.nih.gov/pubmed/34483669
http://dx.doi.org/10.1177/11786469211041368

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