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Neurovascular crosstalk coordinates the central nervous system development
Purpose of the review: The synchronic development of vascular and nervous systems is orchestrated by common molecules that regulate the communication between both systems. The identification of these common guiding cues and the developmental processes regulated by neurovascular communication are slo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Current Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411665/ https://www.ncbi.nlm.nih.gov/pubmed/34077852 http://dx.doi.org/10.1016/j.conb.2021.04.005 |
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author | Peguera, Blanca Segarra, Marta Acker-Palmer, Amparo |
author_facet | Peguera, Blanca Segarra, Marta Acker-Palmer, Amparo |
author_sort | Peguera, Blanca |
collection | PubMed |
description | Purpose of the review: The synchronic development of vascular and nervous systems is orchestrated by common molecules that regulate the communication between both systems. The identification of these common guiding cues and the developmental processes regulated by neurovascular communication are slowly emerging. In this review, we describe the molecules modulating the neurovascular development and their impact in processes such as angiogenesis, neurogenesis, neuronal migration, and brain homeostasis. Recent findings: Blood vessels not only are involved in nutrient and oxygen supply of the central nervous system (CNS) but also exert instrumental functions controlling developmental neurogenesis, CNS cytoarchitecture, and neuronal plasticity. Conversely, neurons modulate CNS vascularization and brain endothelial properties such as blood–brain barrier and vascular hyperemia. Summary: The integration of the active role of endothelial cells in the development and maintenance of neuronal function is important to obtain a more holistic view of the CNS complexity and also to understand how the vasculature is involved in neuropathological conditions. |
format | Online Article Text |
id | pubmed-8411665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Current Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-84116652021-09-03 Neurovascular crosstalk coordinates the central nervous system development Peguera, Blanca Segarra, Marta Acker-Palmer, Amparo Curr Opin Neurobiol Article Purpose of the review: The synchronic development of vascular and nervous systems is orchestrated by common molecules that regulate the communication between both systems. The identification of these common guiding cues and the developmental processes regulated by neurovascular communication are slowly emerging. In this review, we describe the molecules modulating the neurovascular development and their impact in processes such as angiogenesis, neurogenesis, neuronal migration, and brain homeostasis. Recent findings: Blood vessels not only are involved in nutrient and oxygen supply of the central nervous system (CNS) but also exert instrumental functions controlling developmental neurogenesis, CNS cytoarchitecture, and neuronal plasticity. Conversely, neurons modulate CNS vascularization and brain endothelial properties such as blood–brain barrier and vascular hyperemia. Summary: The integration of the active role of endothelial cells in the development and maintenance of neuronal function is important to obtain a more holistic view of the CNS complexity and also to understand how the vasculature is involved in neuropathological conditions. Current Biology 2021-08 /pmc/articles/PMC8411665/ /pubmed/34077852 http://dx.doi.org/10.1016/j.conb.2021.04.005 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Peguera, Blanca Segarra, Marta Acker-Palmer, Amparo Neurovascular crosstalk coordinates the central nervous system development |
title | Neurovascular crosstalk coordinates the central nervous system development |
title_full | Neurovascular crosstalk coordinates the central nervous system development |
title_fullStr | Neurovascular crosstalk coordinates the central nervous system development |
title_full_unstemmed | Neurovascular crosstalk coordinates the central nervous system development |
title_short | Neurovascular crosstalk coordinates the central nervous system development |
title_sort | neurovascular crosstalk coordinates the central nervous system development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411665/ https://www.ncbi.nlm.nih.gov/pubmed/34077852 http://dx.doi.org/10.1016/j.conb.2021.04.005 |
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